Common polymorphism in the promoter of the CD14 monocyte receptor gene is associated with acute myocardial infarction in Japanese men

被引：73

作者：

Shimada, K ^{[1
]}

Watanabe, Y ^{[1
]}

Mokuno, H ^{[1
]}

Iwama, Y ^{[1
]}

Daida, H ^{[1
]}

Yamaguchi, H ^{[1
]}

机构：

[1] Juntendo Univ, Dept Cardiol, Sch Med, Bunkyo Ku, Tokyo 1138421, Japan

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2000年 / 86卷 / 06期

关键词：

D O I：

10.1016/S0002-9149(00)01054-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We investigated whether C(-260)-->T polymorphism in the promoter of the CD14 monocyte receptor gene predisposed to coronary atherosclerosis and acute myocardial infarction (AMT) in Japanese men. The frequencies of T allele and T/T homozygotes in patients with AMI were significantly higher than in controls and in patients with angina without prior AMI, suggesting that the CD14 promoter polymorphism is associated with AMI rather than with coronary atherosclerosis, and this polymorphism may be one of the genetic risk factors for AMI in Japanese men.

引用

页码：682 / +

页数：4

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