学术探索
学术期刊
新闻热点
数据分析
智能评审

The phosphatidylinositol 3-kinase-AKT pathway in human cancer

被引：5018
作者：
Vivanco, I
Sawyers, CL
机构：
[1] Univ Calif Los Angeles, Sch Med, Dept Med, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Sch Med, Dept Urol, Los Angeles, CA 90095 USA
[4] Univ Calif Los Angeles, Sch Med, Inst Mol Biol, Los Angeles, CA 90095 USA
来源：
NATURE REVIEWS CANCER | 2002年 / 2卷 / 07期
关键词：
D O I：
10.1038/nrc839
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
One signal that is overactivated in a wide range of tumour types is the production of a phospholipid, phosphatidylinositol (3,4,5) trisphosphate, by phosphatidylinositol 3-kinase PI3N. This lipid and the protein kinase that is activated by it - AKT - trigger a cascade of responses, from cell growth and proliferation to survival and motility, that drive tumour progression. Small-molecule therapeutics that block PI3K signalling might deal a severe blow-to cancer cells by blocking many aspects of the tumour-cell phenotype.
引用
收藏
页码：489 / 501
页数：13
相关论文
共 160 条
  • [81] SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival
    Liu, QR
    Sasaki, T
    Kozieradzki, I
    Wakeham, A
    Itie, A
    Dumont, DJ
    Penninger, JM
    [J]. GENES & DEVELOPMENT, 1999, 13 (07) : 786 - 791
  • [82] The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
    Maehama, T
    Dixon, JE
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (22) : 13375 - 13378
  • [83] Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane
    Maira, SM
    Galetic, I
    Brazil, DP
    Kaech, S
    Ingley, E
    Thelen, M
    Hemmings, BA
    [J]. SCIENCE, 2001, 294 (5541) : 374 - 380
  • [84] PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy
    Mayo, LD
    Dixon, JE
    Durden, DL
    Tonks, NK
    Donner, DB
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (07) : 5484 - 5489
  • [85] A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus
    Mayo, LD
    Donner, DB
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (20) : 11598 - 11603
  • [86] AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
    Medema, RH
    Kops, GJPL
    Bos, JL
    Burgering, BMT
    [J]. NATURE, 2000, 404 (6779) : 782 - 787
  • [87] The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway
    Mihaylova, VT
    Borland, CZ
    Manjarrez, L
    Stern, MJ
    Sun, H
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (13) : 7427 - 7432
  • [88] The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila
    Miron, M
    Verdú, J
    Lachance, PED
    Birnbaum, MJ
    Lasko, PF
    Sonenberg, N
    [J]. NATURE CELL BIOLOGY, 2001, 3 (06) : 596 - 601
  • [89] Drosophila S6 kinase: A regulator of cell size
    Montagne, J
    Stewart, MJ
    Stocker, H
    Hafen, E
    Kozma, SC
    Thomas, G
    [J]. SCIENCE, 1999, 285 (5436) : 2126 - 2129
  • [90] A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans
    Morris, JZ
    Tissenbaum, HA
    Ruvkun, G
    [J]. NATURE, 1996, 382 (6591) : 536 - 539
45678910111213