An overview of investigational antiapoptotic drugs with potential application for the treatment of neurodegenerative disorders

被引：25

作者：

Camins, Antoni ^{[1
]}

Xavier Sureda, Francesc ^{[2
]}

Junyent, Felix ^{[1
,3
]}

Verdaguer, Ester ^{[1
]}

Folch, Jaume ^{[3
]}

Beas-Zarate, Carlos ^{[4
]}

Pallas, Merce ^{[1
]}

机构：

[1] Nucli Univ Pedralbes, Univ Barcelona,Fac Farm, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Inst Biomed IBUB,Unitat Farmacol & Farmacognosia, Barcelona 08028, Spain

[2] Univ Rovira & Virgili, Unitat Farmacol, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Fac Med & Ciencies Salut, Tarragona 43201, Spain

[3] Univ Rovira & Virgili, Unitat Bioquim, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Fac Med & Ciencies Salut, Tarragona 43201, Spain

[4] Univ Guadalajara, Dept Biol Celular & Mol, Ctr Invest Biomed Occidente, CUCBA,IMSS,Div Neurociencias, Guadalajara 44340, Jalisco, Mexico

来源：

EXPERT OPINION ON INVESTIGATIONAL DRUGS | 2010年 / 19卷 / 05期

关键词：

MITOCHONDRIAL-MEMBRANE PERMEABILIZATION; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; GLYCOGEN-SYNTHASE KINASE-3-BETA; TRANSGENIC MOUSE MODEL; ALZHEIMERS-DISEASE; GINKGO-BILOBA; COENZYME Q(10); TAUROURSODEOXYCHOLIC ACID; PARKINSONS-DISEASE; OXIDATIVE DAMAGE;

D O I：

10.1517/13543781003781898

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Areas covered in this review: The present review discusses some of the drugs that are now under development with antiapoptotic activity or currently on the market that may have a potential application for the treatment of neurodegenerative diseases. Moreover, we also comment on potential compounds such as resveratrol and melatonin. Despite the lack of information from clinical trials on these two compounds, they are attracting considerable attention because of their natural origin and antioxidant and antiapoptotic action. Furthermore, they do not show toxicity in humans. In addition, we discuss the potential application of several compounds, such as NMDA antagonists, JNK inhibitors and GSK-3 inhibitors, for the treatment of neurodegenerative disorders. What the reader will gain: This article will review recent developments in the field of apoptosis inhibitors, which might provide future tools for the treatment of the neurodegenerative diseases. Take home message: The treatment of neurodegenerative diseases is a major challenge in medicine. This is partly because the incidence of these disorders is expected to rise in the coming years. New developments in the field of apoptosis inhibitors may provide future tools for the treatment of the aforementioned neurodegenerative diseases.

引用

页码：587 / 604

页数：18

共 122 条

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