The role of bone turnover markers and risk factors in the assessment of osteoporosis and fracture risk

被引：24

作者：

Clowes, JA ^{[1
]}

Eastell, R ^{[1
]}

机构：

[1] Univ Sheffield, No Gen Hosp, Ctr Clin Sci, Div Clin Sci,NGHT, Sheffield S5 7AU, S Yorkshire, England

来源：

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2000年 / 14卷 / 02期

关键词：

osteoporosis; bone turnover markers; risk factors; osteoporotic fractures;

D O I：

10.1053/beem.2000.0070

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The clinical evaluation of osteoporosis in individual patients involves confirmation of the diagnosis, the investigation of secondary causes of osteoporosis and the evaluation of subsequent fracture risk. Optimum clinical assessment involves bone mineral densitometry with the treatment thresholds modified by clinical risk factors for individual patients. Bone turnover markers and clinical risk factors can be used to identify patients at risk of osteoporotic fracture and those who have secondary osteoporosis. Risk assessment should involve the evaluation of absolute rather than relative risk. Further work is required to improve the integration of clinical risk factors, bone turnover markers and bone densitometry into appropriate models to enable the assessment of the absolute risk of fracture for individual patients.

引用

页码：213 / 232

页数：20

共 102 条

[61] Family history of appendicular fracture and risk of osteoporosis: A population-based study [J].