The Role of PPAR and Its Cross-Talk with CAR and LXR in Obesity and Atherosclerosis

被引：110

作者：

Xu, Pengfei ^{[1
,2
]}

Zhai, Yonggong ^{[1
,2
]}

Wang, Jing ^{[3
]}

机构：

[1] Beijing Normal Univ, Coll Life Sci, Beijing Key Lab Gene Resource & Mol Dev, Beijing 100875, Peoples R China

[2] Beijing Normal Univ, Coll Life Sci, Key Lab Cell Proliferat & Regulat Biol, State Educ Minist, Beijing 100875, Peoples R China

[3] Baotou Teachers Coll, Dept Biol Sci & Technol, Baotou 014030, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 04期

基金：

中国国家自然科学基金;

关键词：

PPAR; CAR; LXR; obesity; atherosclerosis; PROLIFERATOR-ACTIVATED-RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR; LIVER-X-RECEPTOR; REVERSE CHOLESTEROL TRANSPORT; SMALL-MOLECULE MODULATORS; ALPHA GENE-TRANSCRIPTION; FATTY-ACID-METABOLISM; FOAM-CELL-FORMATION; LIPID-METABOLISM; DRUG-METABOLISM;

D O I：

10.3390/ijms19041260

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The prevalence of obesity and atherosclerosis has substantially increased worldwide over the past several decades. Peroxisome proliferator-activated receptors (PPARs), as fatty acids sensors, have been therapeutic targets in several human lipid metabolic diseases, such as obesity, atherosclerosis, diabetes, hyperlipidaemia, and non-alcoholic fatty liver disease. Constitutive androstane receptor (CAR) and liver X receptors (LXRs) were also reported as potential therapeutic targets for the treatment of obesity and atherosclerosis, respectively. Further clarification of the internal relationships between these three lipid metabolic nuclear receptors is necessary to enable drug discovery. In this review, we mainly summarized the cross-talk of PPARs-CAR in obesity and PPARs-LXRs in atherosclerosis.

引用

页数：17

共 145 条

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