Spinning molecular immunology into successful immunotherapy

被引:294
作者
Pardoll, DM [1 ]
机构
[1] Johns Hopkins Univ, Sch Med, Sidney Kimmel Canc Ctr, Baltimore, MD 21231 USA
关键词
D O I
10.1038/nri774
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Until recently, immunotherapies have been of limited success, particularly against cancer. However, recent insights into the cells, molecules and signalling pathways that regulate immune responsiveness are providing new approaches for immunotherapy. In this article, I review some of the most promising molecular and cellular targets for immunotherapy and discuss approaches that use these targets to amplify immune responses and potentially break antigen-specific tolerance. These strategies provide a blueprint for the development of successful immunotherapy over the next decade.
引用
收藏
页码:227 / 238
页数:12
相关论文
共 141 条
  • [1] Agadjanyan MG, 1999, J IMMUNOL, V162, P3417
  • [2] Ahlers JD, 1997, J IMMUNOL, V158, P3947
  • [3] Toll-like receptors: critical proteins linking innate and acquired immunity
    Akira, S
    Takeda, K
    Kaisho, T
    [J]. NATURE IMMUNOLOGY, 2001, 2 (08) : 675 - 680
  • [4] CROSS-PRIMING OF MINOR HISTOCOMPATIBILITY ANTIGEN-SPECIFIC CYTOTOXIC T-CELLS UPON IMMUNIZATION WITH THE HEAT-SHOCK PROTEIN GP96
    ARNOLD, D
    FAATH, S
    RAMMENSEE, HG
    SCHILD, H
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 182 (03) : 885 - 889
  • [5] HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine
    Asea, A
    Kraeft, SK
    Kurt-Jones, EA
    Stevenson, MA
    Chen, LB
    Finberg, RW
    Koo, GC
    Calderwood, SK
    [J]. NATURE MEDICINE, 2000, 6 (04) : 435 - 442
  • [6] High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: Analysis of 270 patients treated between 1985 and 1993
    Atkins, MB
    Lotze, MT
    Dutcher, JP
    Fisher, RI
    Weiss, G
    Margolin, K
    Abrams, J
    Sznol, M
    Parkinson, D
    Hawkins, M
    Paradise, C
    Kunkel, L
    Rosenberg, SA
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 1999, 17 (07) : 2105 - 2116
  • [7] Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b
    Bachmaier, K
    Krawczyk, C
    Kozieradzki, I
    Kong, YY
    Sasaki, T
    Oliveira-dos-Santos, A
    Mariathasan, S
    Bouchard, D
    Wakeham, A
    Itie, A
    Le, J
    Ohashi, PS
    Sarosi, I
    Nishina, H
    Lipkowitz, S
    Penninger, JM
    [J]. NATURE, 2000, 403 (6766) : 211 - 216
  • [8] Dendritic cells and the control of immunity
    Banchereau, J
    Steinman, RM
    [J]. NATURE, 1998, 392 (6673) : 245 - 252
  • [9] Signaling through OX40 (CD134) breaks peripheral T-cell tolerance
    Bansal-Pakala, P
    Jember, AGH
    Croft, M
    [J]. NATURE MEDICINE, 2001, 7 (08) : 907 - 912
  • [10] CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin
    Basu, S
    Binder, RJ
    Ramalingam, T
    Srivastava, PK
    [J]. IMMUNITY, 2001, 14 (03) : 303 - 313