Spinning molecular immunology into successful immunotherapy

被引:294
作者
Pardoll, DM [1 ]
机构
[1] Johns Hopkins Univ, Sch Med, Sidney Kimmel Canc Ctr, Baltimore, MD 21231 USA
关键词
D O I
10.1038/nri774
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Until recently, immunotherapies have been of limited success, particularly against cancer. However, recent insights into the cells, molecules and signalling pathways that regulate immune responsiveness are providing new approaches for immunotherapy. In this article, I review some of the most promising molecular and cellular targets for immunotherapy and discuss approaches that use these targets to amplify immune responses and potentially break antigen-specific tolerance. These strategies provide a blueprint for the development of successful immunotherapy over the next decade.
引用
收藏
页码:227 / 238
页数:12
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共 141 条
  • [31] Dong HD, 1999, NAT MED, V5, P1365
  • [32] VACCINATION WITH IRRADIATED TUMOR-CELLS ENGINEERED TO SECRETE MURINE GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR STIMULATES POTENT, SPECIFIC, AND LONG-LASTING ANTITUMOR IMMUNITY
    DRANOFF, G
    JAFFEE, E
    LAZENBY, A
    GOLUMBEK, P
    LEVITSKY, H
    BROSE, K
    JACKSON, V
    HAMADA, H
    PARDOLL, D
    MULLIGAN, RC
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (08) : 3539 - 3543
  • [33] Lentivirus-transduced human monocyte-derived dendritic cells efficiently stimulate antigen-specific cytotoxic T lymphocytes
    Dyall, J
    Latouche, JB
    Schnell, S
    Sadelain, M
    [J]. BLOOD, 2001, 97 (01) : 114 - 121
  • [34] Heteroclitic immunization induces tumor immunity
    Dyall, R
    Bowne, WB
    Weber, LW
    LeMaoult, J
    Szabo, P
    Moroi, Y
    Piskun, G
    Lewis, JJ
    Houghton, AN
    Nikolic-Zugic, J
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (09) : 1553 - 1561
  • [35] Immunization with type 5 adenovirus recombinant for a tumor antigen in combination with recombinant canarypox virus (ALVAC) cytokine gene delivery induces destruction of established prostate tumors
    Elzey, BD
    Siemens, DR
    Ratliff, TL
    Lubaroff, DM
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2001, 94 (06) : 842 - 849
  • [36] P21-RAS-PEPTIDE-SPECIFIC T-CELL RESPONSES IN A PATIENT WITH COLORECTAL-CANCER - CD4(+) AND CD8(+) T-CELLS RECOGNIZE A PEPTIDE CORRESPONDING TO A COMMON MUTATION (13 GLY-]ASP)
    FOSSUM, B
    GEDDEDAHL, T
    BREIVIK, J
    ERIKSEN, JA
    SPURKLAND, A
    THORSBY, E
    GAUDERNACK, G
    [J]. INTERNATIONAL JOURNAL OF CANCER, 1994, 56 (01) : 40 - 45
  • [37] A K-RAS 13GLY-]ASP MUTATION IS RECOGNIZED BY HLA-DQ7 RESTRICTED T-CELLS IN A PATIENT WITH COLORECTAL-CANCER - MODIFYING EFFECT OF DQ7 ON ESTABLISHED CANCERS HARBORING THIS MUTATION
    FOSSUM, B
    BREIVIK, J
    MELING, GI
    GEDDEDAHL, T
    HANSEN, T
    KNUTSEN, I
    ROGNUM, TO
    THORSBY, E
    GAUDERNACK, G
    [J]. INTERNATIONAL JOURNAL OF CANCER, 1994, 58 (04) : 506 - 511
  • [38] Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
    Freeman, GJ
    Long, AJ
    Iwai, Y
    Bourque, K
    Chernova, T
    Nishimura, H
    Fitz, LJ
    Malenkovich, N
    Okazaki, T
    Byrne, MC
    Horton, HF
    Fouser, L
    Carter, L
    Ling, V
    Bowman, MR
    Carreno, BM
    Collins, M
    Wood, CR
    Honjo, T
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (07) : 1027 - 1034
  • [39] GALLOWAY DA, 1990, MOL BIOL MED, V7, P59
  • [40] Virus subversion of immunity: a structural perspective
    Gewurz, BE
    Gaudet, R
    Tortorella, D
    Wang, EW
    Ploegh, HL
    [J]. CURRENT OPINION IN IMMUNOLOGY, 2001, 13 (04) : 442 - 450