Gastrointestinal hormones and regulation of food intake

被引：38

作者：

Dhillo, WS ^{[1
]}

Bloom, SR ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Fac Med, Dept Metab Med, London W12 0NN, England

来源：

HORMONE AND METABOLIC RESEARCH | 2004年 / 36卷 / 11-12期

关键词：

ghrelin; cholecystokinin (cck); glucagon-like peptide-1 (7-36) amide (glp-1); oxyntomodulin; peptide YY (pyy); pancreatic polypeptide (pp); obesity;

D O I：

10.1055/s-2004-826174

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Obesity has been described as the greatest current threat to human health. In order to design drugs to target obesity, it is essential to understand its physiology and pathophysiology. Several peptides synthesised in the gastrointestinal tract which affect food intake have been identified including ghrelin, cholecystokinin (CCK), glucagon-like peptide-1 (7-36) amide (GLP-1), oxyntomodulin, peptide YY (PYY) and pancreatic polypeptide (PP). These peptides represent potential targets for the design of anti-obesity drugs. In this article we review recent advances in our understanding of food intake by these gastrointestinal hormones.

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页码：846 / 851

页数：6

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