Morphogens as conserved axon guidance cues

被引：80

作者：

Zou, Yimin

Lyuksyutova, Anna I.

机构：

[1] Univ Calif San Diego, Div Biol Sci, Neurobiol Sect, La Jolla, CA 92093 USA

[2] Stanford Univ, Dept Biochem, Stanford, CA 94305 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2007年 / 17卷 / 01期

关键词：

D O I：

10.1016/j.conb.2007.01.006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Morphogen family proteins are now widely appreciated as axon guidance cues. Because their roles as morphogens are highly conserved across phylogeny, their functional conservation in axon guidance is now being rigorously examined. Recent studies suggest that morphogens are important in shaping topographic projections in chick and Drosophila visual systems, a process that occurs even later in development.

引用

收藏

页码：22 / 28

页数：7

相关论文

共 39 条

[1] BMPs as mediators of roof plate repulsion of commissural neurons [J].

Augsburger, A ;

Schuchardt, A ;

Hoskins, S ;

Dodd, J ;

Butler, S .

NEURON, 1999, 24 (01) :127-141

[2] Sonic hedgehog guides commissural axons along the longitudinal axis of the spinal cord [J].

Bourikas, D ;

Pekarik, V ;

Baeriswyl, T ;

Grunditz, Å ;

Sadhu, R ;

Nardó, M ;

Stoeckli, ET .

NATURE NEUROSCIENCE, 2005, 8 (03) :297-304

[3] Novel brain wiring functions for classical morphogens: a role as graded positional cues in axon guidance [J].

Charron, F ;

Tessier-Lavigne, M .

DEVELOPMENT, 2005, 132 (10) :2251-2262

[4] The morphogen Sonic hedgehog is an axonal chemoattractant that collaborates with Netrin-1 in midline axon guidance [J].

Charron, F ;

Stein, E ;

Jeong, J ;

McMahon, AP ;

Tessier-Lavigne, M .

CELL, 2003, 113 (01) :11-23

[5] WNTs in the vertebrate nervous system: From patterning to neuronal connectivity [J].

Ciani, L ;

Salinas, PC .

NATURE REVIEWS NEUROSCIENCE, 2005, 6 (05) :351-U17

[6] Molecular mechanisms of axon guidance [J].

Dickson, BJ .

SCIENCE, 2002, 298 (5600) :1959-1964

[7] Wnts send axons up and down the spinal cord [J].

Dickson, BJ .

NATURE NEUROSCIENCE, 2005, 8 (09) :1130-1132

[8] Topographic guidance labels in a sensory projection to the forebrain [J].

Feldheim, DA ;

Vanderhaeghen, P ;

Hansen, MJ ;

Frisén, J ;

Lu, Q ;

Barbacid, M ;

Flanagan, JG .

NEURON, 1998, 21 (06) :1303-1313

[9] Genetic analysis of ephrin-A2 and ephrin-A5 shows their requirement in multiple aspects of retinocollicular mapping [J].

Feldheim, DA ;

Kim, YI ;

Bergemann, AD ;

Frisén, J ;

Barbacid, M ;

Flanagan, JG .

NEURON, 2000, 25 (03) :563-574

[10] The ephrins and Eph receptors in neural development [J].

Flanagan, JG ;

Vanderhaeghen, P .

ANNUAL REVIEW OF NEUROSCIENCE, 1998, 21 :309-345

← 1 2 3 4 →