Elloxazinones A and B, new aminophenoxazinones from Streptomyces griseus Acta 2871

被引：31

作者：

Graf, Ellen

Schneider, Kathrin

Nicholson, Graeme

Stroebele, Markus

Jones, Amanda L.

Goodfellow, Michael

Beil, Winfried

Suessmuth, Roderich D.

Fiedler, Hans-Peter

机构：

[1] Univ Tubingen, Inst Mikrobiol, D-72076 Tubingen, Germany

[2] Tech Univ Berlin, Inst Chem, D-10623 Berlin, Germany

[3] Univ Tubingen, Inst Organ Chem, D-72076 Tubingen, Germany

[4] Univ Tubingen, Inst Anorgan Chem, D-72076 Tubingen, Germany

[5] Newcastle Univ, Div Biol, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[6] Hannover Med Sch, Inst Pharmakol, D-30625 Hannover, Germany

来源：

JOURNAL OF ANTIBIOTICS | 2007年 / 60卷 / 04期

关键词：

aminophenoxazinones; antitumor activity; Streptomyces; taxonomy; structure elucidation;

D O I：

10.1038/ja.2007.35

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Two new aminophenoxazinone compounds with antitumor activity, elloxazinone A and B, were isolated from the culture filtrate of Streptomyces griseus Acta 2871. Their chemical structures were determined by mass spectrometry, NMR spectroscopy and X-ray analysis. Elloxazinones A and B showed a moderate inhibition of the proliferation of human cells from gastric adenocarcinoma in vitro but a strong inhibition of hepatocellular carcinoma cells whereas elloxazinone B strongly inhibited the proliferation of human breast carcinoma cells.

引用

页码：277 / 284

页数：8

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