In vitro antimycobacterial activities of Physalis angulata L.

被引：62

作者：

Pietro, RCLR

Kashima, S

Sato, DN

Januário, AH

França, SC

机构：

[1] Univ Ribeirao Preto, UNAERP, Dept Ciencias Farmaceut, BR-14096380 Ribeirao Preto, SP, Brazil

[2] Adolfo Lutz Inst, Ribeirao Preto, SP, Brazil

[3] Univ Ribeirao Preto, UNAERP, Dept Biotecnol Vegetal, BR-14096380 Ribeirao Preto, SP, Brazil

来源：

PHYTOMEDICINE | 2000年 / 7卷 / 04期

关键词：

Physalis angulata; plant extract; antimycobacterial; Mycobacterium tuberculosis; mycobacteria;

D O I：

10.1016/S0944-7113(00)80052-5

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

The HIV-tuberculosis co-infection has caused an impact on tuberculosis epidemiology all over the world and the efficacies of the therapeutic schemes traditionally prescribed in the treatment of tuberculosis, such as isoniazid, rifampicin and pyrazinamide, have decreased due to the appearance of multidrug-resistant M. tuberculosis strains (MDR). This work is part of research on natural antimicrobial agents from plant: extracts through bioassay-guided fractionation, by in vitro determination of the minimum inhibitory concentration (MIC) using the microdilution method with Alamar blue oxidation-reduction dye. Crude CHCl3 Physalis angulata extracts and physalin-containing fractions displayed antimycobacterial activity against Mycobacterium tuberculosis, Mycobacterium avium, Mycobacterium kansasii, Mycobacterium malmoense and Mycobacterium intracellulare.

引用

页码：335 / 338

页数：4

共 25 条

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Evaluation of Alamar colorimetric broth microdilution susceptibility testing method for staphylococci and enterococci [J].