Notch signaling: Endocytosis makes delta signal better

被引：67

作者：

Le Borgne, R ^{[1
]}

Schweisguth, F ^{[1
]}

机构：

[1] Ecole Normale Super, CNRS UMR 8542, Dept Biol, F-75230 Paris, France

来源：

CURRENT BIOLOGY | 2003年 / 13卷 / 07期

关键词：

D O I：

10.1016/S0960-9822(03)00199-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Endocytosis of cell surface receptors is involved in down-regulation of receptor activity. Recent findings indicate that, paradoxically, endocytosis of a membrane-spanning ligand may up-regulate receptor activity: the zebrafish E3 ligase Mind bomb promotes the endocytosis of Delta and is required for efficient activation of Notch.

引用

页码：R273 / R275

页数：3

共 14 条

[1] Ubiquitin and the control of protein fate in the secretory and endocytic pathways [J].

Bonifacino, JS ;

Weissman, AM .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1998, 14 :19-57

[2] Xenopus neuralized is a ubiquitin ligase that interacts with XDelta1 and regulates Notch signaling [J].

Deblandre, GA ;

Lai, EC ;

Kintner, C .

DEVELOPMENTAL CELL, 2001, 1 (06) :795-806

[3] Notch and Presenilin: a proteolytic mechanism emerges [J].

Fortini, ME .

CURRENT OPINION IN CELL BIOLOGY, 2001, 13 (05) :627-634

[4] Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by delta [J].

Itoh, M ;

Kim, CH ;

Palardy, G ;

Oda, T ;

Jiang, YJ ;

Maust, D ;

Yeo, SY ;

Lorick, K ;

Wright, GJ ;

Ariza-McNaughton, L ;

Weissman, AM ;

Lewis, J ;

Chandrasekharappa, SC ;

Chitnis, AB .

DEVELOPMENTAL CELL, 2003, 4 (01) :67-82

[5] Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of Delta [J].

Lai, EC ;

Deblandre, GA ;

Kintner, C ;

Rubin, GM .

DEVELOPMENTAL CELL, 2001, 1 (06) :783-794

[6] neuralized functions cell-autonomously to regulate a subset of notch-dependent processes during adult Drosophila development [J].

Lai, EC ;

Rubin, GM .

DEVELOPMENTAL BIOLOGY, 2001, 231 (01) :217-233

[7]

Parks AL, 2000, DEVELOPMENT, V127, P1373

[8] neuralized encodes a peripheral membrane protein involved in Delta signaling and endocytosis [J].

Pavlopoulos, E ;

Pitsouli, C ;

Klueg, KM ;

Muskavitch, AT ;

Moschonas, NK ;

Delidakis, C .

DEVELOPMENTAL CELL, 2001, 1 (06) :807-816

[9] When cell biology meets development: endocytic regulation of signaling pathways [J].

Seto, ES ;

Bellen, HJ ;

Lloyd, TE .

GENES & DEVELOPMENT, 2002, 16 (11) :1314-1336

[10] Requirement for dynamin during notch signaling in Drosophila neurogenesis [J].

Seugnet, L ;

Simpson, P ;

Haenlin, M .

DEVELOPMENTAL BIOLOGY, 1997, 192 (02) :585-598

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