Tritylisation of pyrene, perylene and coronene: a new family of switchable fluorescent labels

被引：13

作者：

Shchepinov, MS

Korshun, VA

Egeland, RD

Southern, EM

机构：

[1] Univ Oxford, Dept Biochem, Oxford OX1 3QU, England

[2] MRC, Mol Biol Lab, Cambridge CB2 2QH, England

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 25期

基金：

英国医学研究理事会;

关键词：

polycyclic aromatic compounds; Friedel-Crafts reactions; Grignard reactions; fluorescence; nucleic acids;

D O I：

10.1016/S0040-4039(00)00737-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of novel fluorescent labels based on pyrene, perylene and coronene is described. Due to the trityl-type structure, their fluorescence may be reversibly switched on and off by changing the pH. This property can be used to expand the palette of fluorophores available for multicolour DNA detection on DNA chips. Some FRET and surface chemistry applications are also demonstrated. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：4943 / 4948

页数：6

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