Dramatic change of regioselectivity in the addition of silylated organolithium reagents with oxazolidines induced by the presence of a titanium salt

被引：10

作者：

Agami, C ^{[1
]}

Comesse, S ^{[1
]}

Kadouri-Puchot, C ^{[1
]}

机构：

[1] Univ Paris 06, UMR 7611, Lab Synth Asymetr, F-75005 Paris, France

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 32期

关键词：

D O I：

10.1016/S0040-4039(00)00947-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Diastereoselective reactions between oxazolidines and organolithium reagents afford beta-amino alcohols having chiral vinyl and alkynylsilane moieties. A meaningful change of regioselectivity, from the alpha- to the gamma-position, occurred when those reactions were performed in the presence of titanium isopropoxide, since allyl and allenylsilane derivatives were thus produced. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：6059 / 6062

页数：4

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