Parkinson's disease: Before the motor symptoms and beyond

被引：19

作者：

Korczyn, Amos D. ^{[1
]}

Gurevich, Tanya ^{[2
]}

机构：

[1] Tel Aviv Univ, Sch Med, IL-69978 Ramat Aviv, Israel

[2] Tel Aviv Med Ctr & Sch Med, Movement Disorders Unit, Tel Aviv, Israel

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2010年 / 289卷 / 1-2期

关键词：

Connectivity; Individual-based models; Object-oriented programming; Landscape genetics; Autocorrelation; LEWY NEURITES; SLEEP; DEMENTIA; DYSFUNCTION; DISTURBANCES; PRAMIPEXOLE; DEPRESSION; MANAGEMENT; DOPAMINE; BODIES;

D O I：

10.1016/j.jns.2009.08.032

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

The understanding of the biology of Parkinson's disease (PD) has advanced rapidly over the past 3 decades In particular, the early pathological changes described by Braak et al and the awareness of extensive and clinically relevant premotor manifestations are of diagnostic and therapeutic importance. We review those manifestations and their contribution to the clarification of the pathophysiologic processes of PD, and discuss the implications for treatment of the disease. (C) 2009 Published by Elsevier B.V

引用

页码：2 / 6

页数：5

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