Diastereocontrolled synthesis of pyrrolidines by nickel promoted tandem cyclization-quenching of aminobromodienes

被引：22

作者：

Cancho, Y

Martín, JM

Martínez, M

Llebaria, A

Moretó, JM

Delgado, A

机构：

[1] Univ Barcelona, Fac Farm, Farmaceut Chem Lab, E-08028 Barcelona, Spain

[2] CSIC, Cid, Dept Quim Organ Biol, ES-08034 Barcelona, Spain

来源：

TETRAHEDRON | 1998年 / 54卷 / 07期

关键词：

D O I：

10.1016/S0040-4020(97)10220-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The nickel promoted tandem cyclization-quenching of tethered aminobromodienes has been extended to the synthesis of 2,3,4-trisubstituted pyrrolidines. By a judicious choice of substituents on the starting aminohalodiene, the diastereoselectivity of the process can be efficiently controlled. When a chiral auxiliary on the nitrogen atom is used, enantiomerically enriched pyrrolidines can be obtained after removal of the auxiliary. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：1221 / 1232

页数：12

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