Plasmodium falciparumin the squirrel monkey (Saimiri sciureus):: infection of non-splenectomised animals as a model for exploring clinical manifestations of malaria

被引：26

作者：

Contamin, H

Behr, C

Mercereau-Puijalon, O

Michel, JC

机构：

[1] Inst Pasteur, Lab Immunol Parasitaire, Cayenne 97306, French Guiana

[2] Inst Pasteur, Ctr Primatol, Cayenne 97306, French Guiana

[3] Inst Pasteur, URA CNRS 1960, Unite Immunol Mol Parasites, F-75724 Paris 15, France

来源：

MICROBES AND INFECTION | 2000年 / 2卷 / 08期

关键词：

malaria; Plasmodium falciparum; Saimiri monkey; fever; spleen; thrombocytopenia; anaemia;

D O I：

10.1016/S1286-4579(00)00401-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Plasmodium falciparum infection in humans leads to a variety of symptoms ranging from an influenza-like syndrome to life-threatening complications. Animal models are useful tools for the detailed analysis of the interaction between both parasite and host factors leading to these various clinical manifestations. In this review, examining the different clinical, parasitological and haematological parameters associated with P. falciparum infection in spleen-intact monkeys, we propose this model as a good alternative for exploring some aspects of the host-parasite relationship in malaria. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

引用

页码：945 / 954

页数：10

共 63 条

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