Synthetic strategy of new powerful tris-bisphosphonic ligands for chelation of uranyl, iron, and cobalt cations

被引：21

作者：

Burgada, Ramon

Bailly, Theodorine

Prange, Thierry

Lecouvey, Marc

机构：

[1] Univ Paris 13, CNRS, UMR 7033, Lab Chim Struct Biomol, F-93017 Bobigny, France

[2] Univ Paris 05, CNRS, UMR 8015, Lab Cristallog & RMN Biol,Fac Pharm 4, F-75006 Paris, France

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 13期

关键词：

gem-bisphosphonates; tripodal ligands; polyamines; amino acids; uranyl ion; iron; cobalt; chelates;

D O I：

10.1016/j.tetlet.2007.01.155

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

New tripodal uranyl ion chelators containing gem-bisphosphonic units have been synthesized. All bisphosphonic units present a side chain with 0, 1, or 2 methylene group terminated by -NH2 or -COd(2)H group. These units were respectively coupled with a -CO2H or -NH2 functions of a suitable tri-functional platform. The shape and size of the new designed ligands were selected and validated through computer molecular modelization. (c) 2007 Elsevier Ltd. All rights reserved.

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页码：2315 / 2319

页数：5

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