Density, ultrasonic velocity and viscosity measurements of four pharmacologically significant drugs in methanol at 25°C

被引：36

作者：

Jahagirdar, DV ^{[1
]}

Arbad, BR ^{[1
]}

Mirgane, SR ^{[1
]}

Lande, MK ^{[1
]}

Shankarwar, AG ^{[1
]}

机构：

[1] Marathwada Univ, Dept Chem, Aurangabad 431004, Maharashtra, India

来源：

JOURNAL OF MOLECULAR LIQUIDS | 1998年 / 75卷 / 01期

关键词：

D O I：

10.1016/S0167-7322(97)00021-4

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Density, ultrasonic velocity and viscosity of four pharmaceutically significant drugs were measured in methanol at 25 degrees C. The apparent molar volume (phi(v)), apparent molar compressibility (phi(K)) and the viscosity B-coefficient were calculated from the experimental data. The variation of phi(v) and phi(K) with a drug concentration is linear. Values of phi(v)o and phi(K)o are used to understand solute-solvent interactions. phi(v)o and B-coefficient show wide divergence depending on the size, shape and structure of a drug, while phi(K)o are close to each other for all the four molecules. The first two parameters show differential solute-solvent interactions, while phi(K)o show that the drugs compress the solvent to the same extent. This observation is supported by B/phi(v)o and solvation numbers (S-n) of the drugs. (C) 1998 Elsevier Science B.V.

引用

页码：33 / 43

页数：11