Reengineering the glutathione S-transferase scaffold:: A rational design strategy pays off

被引：22

作者：

Babbitt, PC

机构：

[1] Univ Calif San Francisco, Dept Biopharmaceut Sci, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94143 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2000年 / 97卷 / 19期

关键词：

D O I：

10.1073/pnas.97.19.10298

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：10298 / 10300

页数：3

共 18 条

[1] RETRACTED: Directed evolution of new catalytic activity using the α/β-barrel scaffold (Retracted article. See vol 417, pg 468, 2002) [J].

Altamirano, MM ;

Blackburn, JM ;

Aguayo, C ;

Fersht, AR .

NATURE, 2000, 403 (6770) :617-622

[2] Structure, catalytic mechanism, and evolution of the glutathione transferases [J].

Armstrong, RN .

CHEMICAL RESEARCH IN TOXICOLOGY, 1997, 10 (01) :2-18

[3]

Bateman A, 2004, NUCLEIC ACIDS RES, V32, pD138, DOI [10.1093/nar/gkp985, 10.1093/nar/gkh121, 10.1093/nar/gkr1065]

[4]

Board PG, 1997, BIOCHEM J, V328, P929

[5] Human glutathione transferase A4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation products [J].

Bruns, CM ;

Hubatsch, I ;

Ridderström, M ;

Mannervik, B ;

Tainer, JA .

JOURNAL OF MOLECULAR BIOLOGY, 1999, 288 (03) :427-439

[6] Tailoring new enzyme functions by rational redesign [J].

Cedrone, F ;

Ménez, A ;

Quéméneur, E .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 2000, 10 (04) :405-410

[7] X-RAY CRYSTAL-STRUCTURES OF CYTOSOLIC GLUTATHIONE S-TRANSFERASES - IMPLICATIONS FOR PROTEIN ARCHITECTURE, SUBSTRATE RECOGNITION AND CATALYTIC FUNCTION [J].

DIRR, H ;

REINEMER, P ;

HUBER, R .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1994, 220 (03) :645-661

[8] Mechanistically diverse enzyme superfamilies: the importance of chemistry in the evolution of catalysis [J].

Gerlt, JA ;

Babbitt, PC .

CURRENT OPINION IN CHEMICAL BIOLOGY, 1998, 2 (05) :607-612

[9]

Mannervik B, 1985, Adv Enzymol Relat Areas Mol Biol, V57, P357

[10]

MURZIN AG, 1995, J MOL BIOL, V247, P536, DOI 10.1016/S0022-2836(05)80134-2

← 1 2 →