Defensins - Non-antibiotic use for vaccine development

被引：31

作者：

Biragyn, A ^{[1
]}

机构：

[1] NIA, Immunol Lab, Gerontol Res Ctr, NIH, Baltimore, MD 21224 USA

来源：

CURRENT PROTEIN & PEPTIDE SCIENCE | 2005年 / 6卷 / 01期

关键词：

antimicrobial peptides; dendritic cells; vaccine carrier;

D O I：

10.2174/1389203053027601

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Vaccines should elicit protective and long lasting immune memory, which depends on well choreographed responses between innate and acquired immunity. Defensins are small host defense peptides of innate immunity hitherto reported to have antimicrobial activity, which also orchestrate chemotaxis and activation of effector immune cells, including immature dendritic cells. This review analyzes the biological meaning of the immunomodulatory and immunoenhancing features of defensins and their use for the development of novel vaccines to combat cancer and clinically relevant diseases.

引用

页码：53 / 60

页数：8

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