The hypothalamic endocannabinoid system participates in the secretion of oxytocin and tumor necrosis factor-alpha induced by lipopolysaccharide

被引：31

作者：

De Laurentiis, Andrea ^{[1
]}

Fernandez-Solari, Javier ^{[1
]}

Mohn, Claudia ^{[1
]}

Burdet, Berenice ^{[1
]}

Zorrilla Zubilete, Maria A. ^{[1
]}

Rettori, Valeria ^{[1
]}

机构：

[1] Univ Buenos Aires, Fac Med, Ctr Estudios Farmacol & Bot, CONICET, Buenos Aires, DF, Argentina

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2010年 / 221卷 / 1-2期

关键词：

Anandamide; Cannabinoid receptors; Nitric oxide synthase; Cytokines; Hypothalamus; NITRIC-OXIDE SYNTHASE; PITUITARY-ADRENAL AXIS; ACID AMIDE HYDROLASE; CANNABINOID RECEPTORS; VASOPRESSIN NEURONS; HORMONE-SECRETION; RELEASE; RAT; CYTOKINES; RESPONSES;

D O I：

10.1016/j.jneuroim.2010.02.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This study investigated the participation of the hypothalamic endocannabinoid system in the response to lipopolysaccharide (LPS) challenge evaluating oxytocin (OXT) and tumor necrosis factor-alpha (TNF-a) plasma levels in vivo and their release from hypothalamic fragments in vitro. LPS increased OXT and TNF-a release through anandamide-activation of hypothalamic cannabinoid receptor CB(1), since the antagonist AM251 blocked this effect. Anandamide, through its receptors, also increased hypothalamic nitric oxide (NO) which inhibited OXT release, ending the stimulatory effect of the endocannabinoid. Our findings reveal a hypothalamic interaction between oxytocin, endocannabinoid and NO-ergic systems providing a regulation of the hypothalamic-neurohypophyseal axis under basal and stress conditions. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：32 / 41

页数：10

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