The hypothalamic endocannabinoid system participates in the secretion of oxytocin and tumor necrosis factor-alpha induced by lipopolysaccharide

被引：31

作者：

De Laurentiis, Andrea ^{[1
]}

Fernandez-Solari, Javier ^{[1
]}

Mohn, Claudia ^{[1
]}

Burdet, Berenice ^{[1
]}

Zorrilla Zubilete, Maria A. ^{[1
]}

Rettori, Valeria ^{[1
]}

机构：

[1] Univ Buenos Aires, Fac Med, Ctr Estudios Farmacol & Bot, CONICET, Buenos Aires, DF, Argentina

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2010年 / 221卷 / 1-2期

关键词：

Anandamide; Cannabinoid receptors; Nitric oxide synthase; Cytokines; Hypothalamus; NITRIC-OXIDE SYNTHASE; PITUITARY-ADRENAL AXIS; ACID AMIDE HYDROLASE; CANNABINOID RECEPTORS; VASOPRESSIN NEURONS; HORMONE-SECRETION; RELEASE; RAT; CYTOKINES; RESPONSES;

D O I：

10.1016/j.jneuroim.2010.02.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This study investigated the participation of the hypothalamic endocannabinoid system in the response to lipopolysaccharide (LPS) challenge evaluating oxytocin (OXT) and tumor necrosis factor-alpha (TNF-a) plasma levels in vivo and their release from hypothalamic fragments in vitro. LPS increased OXT and TNF-a release through anandamide-activation of hypothalamic cannabinoid receptor CB(1), since the antagonist AM251 blocked this effect. Anandamide, through its receptors, also increased hypothalamic nitric oxide (NO) which inhibited OXT release, ending the stimulatory effect of the endocannabinoid. Our findings reveal a hypothalamic interaction between oxytocin, endocannabinoid and NO-ergic systems providing a regulation of the hypothalamic-neurohypophyseal axis under basal and stress conditions. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：32 / 41

页数：10

共 58 条

[51] INHIBITION OF SUCKLING-INDUCED MILK EJECTIONS IN THE LACTATING RAT BY DELTA-9-TETRAHYDROCANNABINOL [J].

TYREY, L ;

MURPHY, LL .

ENDOCRINOLOGY, 1988, 123 (01) :469-472

[52] Endovanilloids - Putative endogenous ligands of transient receptor potential vanilloid 1 channels [J].

van der Stelt, M ;

Di Marzo, V .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 2004, 271 (10) :1827-1834

[53] CYTOKINE-TO-BRAIN COMMUNICATION - A REVIEW AND ANALYSIS OF ALTERNATIVE MECHANISMS [J].

WATKINS, LR ;

MAIER, SF ;

GOEHLER, LE .

LIFE SCIENCES, 1995, 57 (11) :1011-1026

[54] Immune activation: The role of pro-inflammatory cytokines in inflammation, illness responses and pathological pain states [J].

Watkins, LR ;

Maier, SF ;

Goehler, LE .

PAIN, 1995, 63 (03) :289-302

[55] EFFECT OF THE BRAIN CONSTITUENT ANANDAMIDE, A CANNABINOID RECEPTOR AGONIST, ON THE HYPOTHALAMO-PITUTARY-ADRENAL AXIS IN THE RAT [J].

WEIDENFELD, J ;

FELDMAN, S ;

MECHOULAM, R .

NEUROENDOCRINOLOGY, 1994, 59 (02) :110-112

[56] The role of endocannabinoids in the hypothalamic regulation of visceral function [J].

Wenger, T ;

Moldrich, G .

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 2002, 66 (2-3) :301-307

[57] Differential neuronal activation in the hypothalamic paraventricular nucleus and autonomic/neuroendocrine responses to i.c.v. endotoxin [J].

Xia, Y ;

Krukoff, TL .

NEUROSCIENCE, 2003, 121 (01) :219-231

[58] The distribution of neural nitric oxide synthase-positive cerebrospinal fluid-contacting neurons in the third ventricular wall of male rats and coexistence with vasopressin or oxytocin [J].

Xiao, M ;

Ding, J ;

Wu, LX ;

Han, QY ;

Wang, HM ;

Zuo, GP ;

Hu, G .

BRAIN RESEARCH, 2005, 1038 (02) :150-162

← 1 2 3 4 5 6 →