The Great Escape: Viral Strategies to Counter BST-2/Tetherin

被引：98

作者：

Douglas, Janet L. ^{[1
]}

Gustin, Jean K. ^{[1
]}

Viswanathan, Kasinath ^{[1
]}

Mansouri, Mandana ^{[1
]}

Moses, Ashlee V. ^{[1
]}

Frueh, Klaus ^{[1
]}

机构：

[1] Oregon Hlth & Sci Univ, Vaccine & Gene Therapy Inst, Beaverton, OR USA

来源：

PLOS PATHOGENS | 2010年 / 6卷 / 05期

关键词：

TYPE-1 VPU PROTEIN; TETHERIN-MEDIATED RESTRICTION; HIV-1 VIRUS RELEASE; CELL-SURFACE; PARTICLE RELEASE; MOLECULAR-CLONING; ENVELOPE PROTEIN; INHIBITS HIV-1; BETA-TRCP; DEGRADATION;

D O I：

10.1371/journal.ppat.1000913

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The interferon-induced BST-2 protein has the unique ability to restrict the egress of HIV-1, Kaposi's sarcoma-associated herpesvirus (KSHV), Ebola virus, and other enveloped viruses. The observation that virions remain attached to the surface of BST-2-expressing cells led to the renaming of BST-2 as "tetherin". However, viral proteins such as HIV-1 Vpu, simian immunodeficiency virus Nef, and KSHV K5 counteract BST-2, thereby allowing mature virions to readily escape from infected cells. Since the anti-viral function of BST-2 was discovered, there has been an explosion of research into several aspects of this intriguing interplay between host and virus. This review focuses on recent work addressing the molecular mechanisms involved in BST-2 restriction of viral egress and the species-specific countermeasures employed by various viruses.

引用

页码：1 / 12

页数：12

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