Synthesis of side chain truncated apicularen A

被引：81

作者：

Bhattacharjee, A ^{[1
]}

De Brabander, JK ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Dept Biochem, Dallas, TX 75390 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 42期

关键词：

antitumor compounds; natural products; hetero Diels-Alder;

D O I：

10.1016/S0040-4039(00)01403-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The potent cytostatic agent apicularen A belongs to a growing class of macrocyclic salicylates with unique biological properties. Herein, we present a short enantioselective synthesis of side chain truncated apicularen A. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：8069 / 8073

页数：5

共 21 条

[1] SILOXY DIENES IN TOTAL SYNTHESIS [J].

DANISHEFSKY, S .

ACCOUNTS OF CHEMICAL RESEARCH, 1981, 14 (12) :400-406

[2] Novel lactone compounds from Mortierella verticillata that induce the human low density lipoprotein receptor gene:: Fermentation, isolation, structural elucidation and biological activities [J].

Dekker, KA ;

Aiello, RJ ;

Hirai, H ;

Inagaki, T ;

Sakakibara, T ;

Suzuki, Y ;

Thompson, JF ;

Yamauchi, Y ;

Kojima, N .

JOURNAL OF ANTIBIOTICS, 1998, 51 (01) :14-20

[3]

Dossetter AG, 1999, ANGEW CHEM INT EDIT, V38, P2398, DOI 10.1002/(SICI)1521-3773(19990816)38:16<2398::AID-ANIE2398>3.0.CO

[4]

2-E

[5] Salicylihalamides A and B, novel cytotoxic macrolides from the marine sponge Haliclona sp. [J].

Erickson, KL ;

Beutler, JA ;

Cardellina, JH ;

Boyd, MR .

JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (23) :8188-8192

[6]

EVANS DA, 1996, J AM CHEM SOC, V118, P432

[7]

Jansen R, 2000, EUR J ORG CHEM, V2000, P913, DOI 10.1002/(SICI)1099-0690(200003)2000:6<913::AID-EJOC913>3.0.CO

[8]

2-L

[9] ON THE ORIGINS OF STEREOSELECTIVITY IN CHELATION CONTROLLED NUCLEOPHILIC ADDITIONS TO BETA-ALKOXY ALDEHYDES - SOLUTION STRUCTURES OF LEWIS ACID COMPLEXES VIA NMR-SPECTROSCOPY [J].

KECK, GE ;

CASTELLINO, S .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (13) :3847-3849

[10] Oximidines I and II:: Novel antitumor macrolides from Pseudomonas sp. [J].

Kim, JW ;

Shin-ya, K ;

Furihata, K ;

Hayakawa, Y ;

Seto, H .

JOURNAL OF ORGANIC CHEMISTRY, 1999, 64 (01) :153-155

← 1 2 3 →