The Role of Excitatory Amino Acid Transporters in Cerebral Ischemia

被引:78
作者
Chao, Xiao-dong [1 ]
Fei, Fei [2 ,3 ]
Fei, Zhou [1 ]
机构
[1] Fourth Mil Med Univ, Xi Jing Hosp, Dept Neurosurg, Xian 710032, Peoples R China
[2] Fourth Mil Med Univ, Canc Biol State Key Lab, Cell Engn Res Ctr, Dept Cell Biol, Xian 710032, Peoples R China
[3] Fourth Mil Med Univ, State Key Discipline Cell Biol, Xian 710032, Peoples R China
基金
中国国家自然科学基金;
关键词
EAAT2; Cerebral ischemia; Glutamate (Glu); Excitatory amino acid transporters (EAATs); GLIAL GLUTAMATE TRANSPORTERS; MOLECULAR PHARMACOLOGY; NEURONAL EXPRESSION; DOWN-REGULATION; UP-REGULATION; ASTROCYTES; INDUCTION; CLONING; CELLS; GLAST;
D O I
10.1007/s11064-010-0178-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Glutamate is an excitatory neurotransmitter that plays a major role in the pathogenesis of ischemia brain injury. The regulation of glutamate neurotransmission is carried out by excitatory amino acid transporters (EAATs) that act through reuptake of glutamate into cells. EAATs may also release glutamate into the extracellular space in a calcium-independent manner during ischemia and dysfunction of EAATs is specifically implicated in the pathology of cerebral ischemia. Recent studies show that up-regulation of EAAT2 provides neuroprotection during ischemic insult. This review summarizes current knowledge regarding the role of EAATs in cerebral ischemia.
引用
收藏
页码:1224 / 1230
页数:7
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