The Role of Excitatory Amino Acid Transporters in Cerebral Ischemia

被引：78

作者：

Chao, Xiao-dong ^{[1
]}

Fei, Fei ^{[2
,3
]}

Fei, Zhou ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Xi Jing Hosp, Dept Neurosurg, Xian 710032, Peoples R China

[2] Fourth Mil Med Univ, Canc Biol State Key Lab, Cell Engn Res Ctr, Dept Cell Biol, Xian 710032, Peoples R China

[3] Fourth Mil Med Univ, State Key Discipline Cell Biol, Xian 710032, Peoples R China

来源：

NEUROCHEMICAL RESEARCH | 2010年 / 35卷 / 08期

基金：

中国国家自然科学基金;

关键词：

EAAT2; Cerebral ischemia; Glutamate (Glu); Excitatory amino acid transporters (EAATs); GLIAL GLUTAMATE TRANSPORTERS; MOLECULAR PHARMACOLOGY; NEURONAL EXPRESSION; DOWN-REGULATION; UP-REGULATION; ASTROCYTES; INDUCTION; CLONING; CELLS; GLAST;

D O I：

10.1007/s11064-010-0178-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glutamate is an excitatory neurotransmitter that plays a major role in the pathogenesis of ischemia brain injury. The regulation of glutamate neurotransmission is carried out by excitatory amino acid transporters (EAATs) that act through reuptake of glutamate into cells. EAATs may also release glutamate into the extracellular space in a calcium-independent manner during ischemia and dysfunction of EAATs is specifically implicated in the pathology of cerebral ischemia. Recent studies show that up-regulation of EAAT2 provides neuroprotection during ischemic insult. This review summarizes current knowledge regarding the role of EAATs in cerebral ischemia.

引用

页码：1224 / 1230

页数：7

共 79 条

[21] Posttraumatic secondary brain insults exacerbates neuronal injury by altering metabotropic glutamate receptors [J].

Fei, Zhou ;

Zhang, Xiang ;

Bai, Hong-Min ;

Jiang, Xiao-Fan ;

Li, Xia ;

Zhang, Wei ;

Hu, Wei .

BMC NEUROSCIENCE, 2007, 8 (1)

[22] Altered expressions of glutamate transporter subtypes in rat model of neonatal cerebral hypoxia-ischemia [J].

Fukamachi, S ;

Furuta, A ;

Ikeda, T ;

Ikenoue, T ;

Kaneoka, T ;

Rothstein, JD ;

Iwaki, T .

DEVELOPMENTAL BRAIN RESEARCH, 2001, 132 (02) :131-139

[23] Cellular and synaptic localization of the neuronal glutamate transporters excitatory amino acid transporter 3 and 4 [J].

Furuta, A ;

Martin, LJ ;

Lin, CLG ;

DykesHoberg, M ;

Rothstein, JD .

NEUROSCIENCE, 1997, 81 (04) :1031-1042

[24] Electrogenic glutamate transporters in the CNS: Molecular mechanism, pre-steady-state kinetics, and their impact on synaptic signaling [J].

Grewer, C ;

Rauen, T .

JOURNAL OF MEMBRANE BIOLOGY, 2005, 203 (01) :1-20

[25] Inhibition of astroglial glutamate transport by polyunsaturated fatty acids: Evidence for a signalling role of docosahexaenoic acid [J].

Grintal, Barbara ;

Champeil-Potokar, Gaelle ;

Lavialle, Monique ;

Vancassel, Sylvie ;

Breton, Sylvie ;

Denis, Isabelle .

NEUROCHEMISTRY INTERNATIONAL, 2009, 54 (08) :535-543

[26] Gliotoxicity in hippocampal cultures is induced by transportable, but not by nontransportable, glutamate uptake inhibitors [J].

Guiramand, J ;

Martin, A ;

Ferreira, MCJ ;

Cohen-Solal, C ;

Vignes, M ;

Récasens, M .

JOURNAL OF NEUROSCIENCE RESEARCH, 2005, 81 (02) :199-207

[27]

HANNAH EB, 2008, GLIA, V56, P998

[28] Up-regulation of endothelial nitric oxide synthase via phosphatidylinositol 3-kinase pathway contributes to ischemic tolerance in the CA1 subfield of gerbil hippocampus [J].

Hashiguchi, A ;

Yano, S ;

Morioka, M ;

Hamada, J ;

Ushio, Y ;

Takeuchi, T ;

Fukunaga, T .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2004, 24 (03) :271-279

[29] Neuronal glutamate transporter EAAT4 is expressed in astrocytes [J].

Hu, WH ;

Walters, WM ;

Xia, XM ;

Karmally, SA ;

Bethea, JR .

GLIA, 2003, 44 (01) :13-25

[30] Isoflurane induces a protein kinase Cα-dependent increase in cell-surface protein level and activity of glutamate transporter type 3 [J].

Huang, YM ;

Zuo, ZY .

MOLECULAR PHARMACOLOGY, 2005, 67 (05) :1522-1533

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