Effects of dentin on the antimicrobial properties of endodontic medicaments

被引:144
作者
Haapasalo, Markus
Qian, Wei
Portenier, Isabelle
Waltimo, Tuomas
机构
[1] Univ British Columbia, Fac Dent, Div Endodont Oral Biol & Med Sci, Vancouver, BC V6T 1Z3, Canada
[2] Univ Oslo, Dept Endodont, Fac Dent, N-0316 Oslo, Norway
[3] Univ Basel, Ctr Dent Med, Dept Prevent Dent & Oral Microbiol, CH-4003 Basel, Switzerland
关键词
bioglass; chlorhexidine; dentin; disinfection; ecology; endodontics; Enterococcus faecalis; inhibition; iodine; MTAD; sodium hypochlorite;
D O I
10.1016/j.joen.2007.04.008
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Successful treatment of apical periodontitis is dependent on the elimination of the infective microflora from the necrotic root canal system. Antimicrobial irrigating solutions and other locally used disinfecting agents and medicaments have a key role in the eradication of the microbes. While most if not all presently used disinfecting agents rapidly kill even the resistant microbes when tested in vitro in a test tube, the effectiveness of the same agents is clearly weaker in the in vivo conditions. Recent studies have given valuable information about the interaction of endodontic disinfecting agents with dentin and other compounds present in the necrotic root canal. As a result of such interactions the antimicrobial effectiveness of several of our key disinfectants may be weakened, or even eliminated under certain circumstances. Different disinfectants show different sensitivity to the action by the various potential inactivators, such as dentin, serum proteins, hydroxyapatite, collagen derived from different sources, and microbial biomass. This review is a summary of our present knowledge of the mostly negative interactions between endodontic disinfecting agents and the various compounds present in the root canal environment.
引用
收藏
页码:917 / 925
页数:9
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