The dynamic genome of Hydra

被引：592

作者：

Chapman, Jarrod A. ^{[2
]}

Kirkness, Ewen F. ^{[3
]}

Simakov, Oleg ^{[4
,5
]}

Hampson, Steven E. ^{[6
]}

Mitros, Therese ^{[5
]}

Weinmaier, Thomas ^{[7
]}

Rattei, Thomas ^{[7
]}

Balasubramanian, Prakash G. ^{[4
]}

Borman, Jon ^{[3
]}

Busam, Dana ^{[3
]}

Disbennett, Kathryn ^{[3
]}

Pfannkoch, Cynthia ^{[3
]}

Sumin, Nadezhda ^{[3
]}

Sutton, Granger G. ^{[3
]}

Viswanathan, Lakshmi Devi ^{[3
]}

Walenz, Brian ^{[3
]}

Goodstein, David M. ^{[2
]}

Hellsten, Uffe ^{[2
]}

Kawashima, Takeshi ^{[5
]}

Prochnik, Simon E. ^{[2
]}

Putnam, Nicholas H. ^{[2
,5
]}

Shu, Shengquiang ^{[2
]}

Blumberg, Bruce ^{[1
,8
]}

Dana, Catherine E. ^{[1
,9
]}

Gee, Lydia ^{[1
,8
]}

Kibler, Dennis F. ^{[6
]}

Law, Lee ^{[1
,8
]}

Lindgens, Dirk ^{[1
,8
]}

Martinez, Daniel E. ^{[10
]}

Peng, Jisong ^{[1
,8
]}

Wigge, Philip A. ^{[11
]}

Bertulat, Bianca ^{[4
]}

Guder, Corina ^{[4
]}

Nakamura, Yukio ^{[4
]}

Ozbek, Suat ^{[4
]}

Watanabe, Hiroshi ^{[4
]}

Khalturin, Konstantin ^{[12
]}

Hemmrich, Georg ^{[12
]}

Franke, Andre ^{[12
]}

Augustin, Rene ^{[12
]}

Fraune, Sebastian ^{[12
]}

Hayakawa, Eisuke ^{[13
]}

Hayakawa, Shiho ^{[13
]}

Hirose, Mamiko ^{[13
]}

Hwang, Jung Shan ^{[13
]}

Ikeo, Kazuho ^{[13
]}

Nishimiya-Fujisawa, Chiemi ^{[13
]}

Ogura, Atshushi ^{[13
]}

Takahashi, Toshio ^{[14
]}

Steinmetz, Patrick R. H. ^{[15
]}

机构：

[1] Univ Calif Irvine, Ctr Dev Biol, Irvine, CA 92717 USA

[2] US DOE, Joint Genome Inst, Walnut Creek, CA 94598 USA

[3] J Craig Venter Inst, Rockville, MD 20850 USA

[4] Heidelberg Univ, Dept Mol Evolut & Genom, Inst Zool, D-69120 Heidelberg, Germany

[5] Univ Calif Berkeley, Dept Mol & Cell Biol, Ctr Integrat Genom, Berkeley, CA 94720 USA

[6] Univ Calif Irvine, Dept Comp Sci, Irvine, CA 92697 USA

[7] Tech Univ Munich, Dept Genome Oriented Bioinformat, D-85354 Freising Weihenstephan, Germany

[8] Univ Calif Irvine, Dept Dev & Cell Biol, Irvine, CA 92717 USA

[9] Univ Calif Irvine, Dept Biol Chem, Irvine, CA 92697 USA

[10] Pomona Coll, Dept Biol, Claremont, CA 91711 USA

[11] Salk Inst Biol Studies, La Jolla, CA 92037 USA

[12] Univ Kiel, Inst Zool, D-24098 Kiel, Germany

[13] Natl Inst Genet, Mishima, Shizuoka 4118540, Japan

[14] Suntory Inst Bioorgan Res, Osaka 6188503, Japan

[15] Univ Vienna, Dept Mol Evolut & Dev, A-1090 Vienna, Austria

[16] Univ Kansas, Med Ctr, Dept Anat & Cell Biol, Kansas City, KS 66160 USA

[17] Univ Innsbruck, Inst Zool, A-6020 Innsbruck, Austria

[18] Univ Innsbruck, Ctr Mol Biosci, A-6020 Innsbruck, Austria

[19] Dartmouth Coll, Dept Biol Sci, Hanover, NH 03755 USA

[20] N Carolina State Univ, Dept Comp Sci, Raleigh, NC 27695 USA

[21] Univ Munich, Dept Biol 2, D-82152 Planegg Martinsried, Germany

来源：

NATURE | 2010年 / 464卷 / 7288期

基金：

奥地利科学基金会; 美国国家科学基金会;

关键词：

TYROSINE KINASE; SEA-ANEMONE; STEM-CELLS; GENE; MOLECULES; MAINTENANCE; EXPRESSION; EVOLUTION; ORIGINS; CLUSTER;

D O I：

10.1038/nature08830

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The freshwater cnidarian Hydra was first described in 1702(1) and has been the object of study for 300 years. Experimental studies of Hydra between 1736 and 1744 culminated in the discovery of asexual reproduction of an animal by budding, the first description of regeneration in an animal, and successful transplantation of tissue between animals(2). Today, Hydra is an important model for studies of axial patterning(3), stem cell biology(4) and regeneration(5). Here we report the genome of Hydra magnipapillata and compare it to the genomes of the anthozoan Nematostella vectensis(6) and other animals. The Hydra genome has been shaped by bursts of transposable element expansion, horizontal gene transfer, trans-splicing, and simplification of gene structure and gene content that parallel simplification of the Hydra life cycle. We also report the sequence of the genome of a novel bacterium stably associated with H. magnipapillata. Comparisons of the Hydra genome to the genomes of other animals shed light on the evolution of epithelia, contractile tissues, developmentally regulated transcription factors, the Spemann-Mangold organizer, pluripotency genes and the neuromuscular junction.

引用

页码：592 / 596

页数：5

共 30 条

[1] Evolution of gap junctions:: The missing link? [J].

Alexopoulos, H ;

Böttger, A ;

Fischer, S ;

Levin, A ;

Wolf, A ;

Fujisawa, T ;

Hayakawa, S ;

Gojobori, T ;

Davies, JA ;

David, CN ;

Bacon, JP .

CURRENT BIOLOGY, 2004, 14 (20) :R879-R880

[2]

Bode PM., 1984, PATTERNING HYDRA, P213

[3] Expression of a novel receptor tyrosine kinase gene and a paired-like homeobox gene provides evidence of differences in patterning at the oral and aboral ends of hydra [J].

Bridge, DM ;

Stover, NA ;

Steele, RE .

DEVELOPMENTAL BIOLOGY, 2000, 220 (02) :253-262

[4] Formation of the head organizer in hydra involves the canonical Wnt pathway [J].

Broun, M ;

Gee, L ;

Reinhardt, B ;

Bode, HR .

DEVELOPMENT, 2005, 132 (12) :2907-2916

[5] The production of new hydranths in Hydra by the insertion of small grafts [J].

Browne, EN .

JOURNAL OF EXPERIMENTAL ZOOLOGY, 1909, 7 (01) :1-U13

[6] The Urbilaterian Super-Hox cluster [J].

Butts, Thomas ;

Holland, Peter W. H. ;

Ferrier, David E. K. .

TRENDS IN GENETICS, 2008, 24 (06) :259-262

[7] Minimal ProtoHox cluster inferred from bilaterian and cnidarian Hox complements [J].

Chourrout, D. ;

Delsuc, F. ;

Chourrout, P. ;

Edvardsen, R. B. ;

Rentzsch, F. ;

Renfer, E. ;

Jensen, M. F. ;

Zhu, B. ;

de Jong, P. ;

Steele, R. E. ;

Technau, U. .

NATURE, 2006, 442 (7103) :684-687

[8]

DAVID CN, 1977, DEV BIOL, V58, P372, DOI 10.1016/0012-1606(77)90098-7

[9] Proposals of Curvibacter gracilis gen. nov., sp nov and Herbaspirillum putei sp nov for bacterial strains isolated from well water and reclassification of [Pseudomonas] huttiensis, [Pseudomonas] lanceolata, [Aquaspirillum] delicatum and [Aquaspirillum] autotrophicum as Herbaspirillum huttiense comb. nov., Curvibacter lanceolatus comb. nov., Curvibacter delicatus comb. nov and Herbaspirillum autotrophicum comb. nov. [J].

Ding, LX ;

Yokota, A .

INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, 2004, 54 :2223-2230

[10] Evidence for Multiple Independent Origins of trans-Splicing in Metazoa [J].

Douris, Vassilis ;

Telford, Maximilian J. ;

Averof, Michalis .

MOLECULAR BIOLOGY AND EVOLUTION, 2010, 27 (03) :684-693

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