Development of a modified beta-cyclodextrin based fluorosensor for dipyridamole

被引：4

作者：

Gong, ZL

Zhang, ZJ ^{[1
]}

机构：

[1] Shaanxi Normal Univ, Dept Chem, Xian 710062, Peoples R China

[2] Nanjing Univ, Dept Chem, Nanjing 210093, Peoples R China

来源：

FRESENIUS JOURNAL OF ANALYTICAL CHEMISTRY | 1998年 / 360卷 / 01期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1007/s002160050662

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

2,6-O-diethyl-beta-cyclodextrins were prepared and immobilized onto silica gel to develop a fluorosensor for dipyridamole. The analytical performance characteristics of the proposed sensor for analysis of dipyridamole were as follows: the detection limit was 0.8 nmol/L with a relative standard deviation of 1.4% for 10 determinations of 50 nmol/L of dipyridamole. The modification of beta-CD improved the sensitivity and selectivity for measuring dipyridamole. The recommended method has been successfully tested for the determination of dipyridamole in clinical samples (urine and pharmaceutical preparations).

引用

页码：138 / 140

页数：3

共 13 条

[1]

BARARY MH, 1989, ANAL LETT, V22, P1643

[2]

DEBALLON C, 1987, J PHARM BIOMED ANAL, V6, P1045

[3] RETENTION BEHAVIOR OF SOME AROMATIC-COMPOUNDS ON CHEMICALLY BONDED CYCLODEXTRIN SILICA STATIONARY PHASE IN LIQUID-CHROMATOGRAPHY [J].