Proteophosphoglycans of Leishmania

被引：113

作者：

Ilg, T ^{[1
]}

机构：

[1] Max Planck Inst Biol, Abt Membranbiochem, D-72076 Tubingen, Germany

来源：

PARASITOLOGY TODAY | 2000年 / 16卷 / 11期

关键词：

D O I：

10.1016/S0169-4758(00)01791-9

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Proteophosphoglycans are an expanding family of highly glycosylated Leishmania proteins with many unusual and some unique structural features. The novel protein-glycan linkage in proteophosphoglycans - phosphoglycosylation of Ser by lipophosphoglycan-like structures - emerges as a major form of protein glycosylation in Leishmania. Here, Thomas Ilg reviews the chemical structure, the ultra-structure, the genes and the potential functions of different members of this novel family of parasite glycoproteins.

引用

页码：489 / 497

页数：9

共 64 条

[1] Proteophosphoglycan, a major secreted product of intracellular Leishmania mexicana amastigotes, is a poor B-cell antigen and does not elicit a specific conventional CD4+ T-cell response [J].

Aebischer, T ;

Harbecke, D ;

Ilg, T .

INFECTION AND IMMUNITY, 1999, 67 (10) :5379-5385

[2] Species-specificity in endoplasmic reticulum signal peptide utilization revealed by proteins from Trypanosoma brucei and Leishmania [J].

Al-Qahtani, A ;

Teilhet, M ;

Mensa-Wilmot, K .

BIOCHEMICAL JOURNAL, 1998, 331 :521-529

[3] PARASITOPHOROUS VACUOLES OF LEISHMANIA-AMAZONENSIS-INFECTED MACROPHAGES MAINTAIN AN ACIDIC PH [J].

ANTOINE, JC ;

PRINA, E ;

JOUANNE, C ;

BONGRAND, P .

INFECTION AND IMMUNITY, 1990, 58 (03) :779-787

[4] EXPRESSION OF LIPOPHOSPHOGLYCAN, HIGH-MOLECULAR-WEIGHT PHOSPHOGLYCAN AND GLYCOPROTEIN-63 IN PROMASTIGOTES AND AMASTIGOTES OF LEISHMANIA-MEXICANA [J].

BAHR, V ;

STIERHOF, YD ;

ILG, T ;

DEMAR, M ;

QUINTEN, M ;

OVERATH, P .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1993, 58 (01) :107-121

[5] LEISHMANIA-DONOVANI - IMMUNOCHEMICAL LOCALIZATION AND SECRETORY MECHANISM OF SOLUBLE ACID-PHOSPHATASE [J].

BATES, PA ;

HERMES, I ;

DWYER, DM .

EXPERIMENTAL PARASITOLOGY, 1989, 68 (03) :335-346

[6] GOLGI-MEDIATED POSTTRANSLATIONAL PROCESSING OF SECRETORY ACID-PHOSPHATASE BY LEISHMANIA-DONOVANI PROMASTIGOTES [J].

BATES, PA ;

HERMES, I ;

DWYER, DM .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1990, 39 (02) :247-256

[7] MODIFICATION OF SAND FLY BITING BEHAVIOR BY LEISHMANIA LEADS TO INCREASED PARASITE TRANSMISSION [J].

BEACH, R ;

KIILU, G ;

LEEUWENBURG, J .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1985, 34 (02) :278-282

[8] Lipophosphoglycan (LPG) and the identification of virulence genes in the protozoan parasite Leishmania [J].

Beverley, SM ;

Turco, SJ .

TRENDS IN MICROBIOLOGY, 1998, 6 (01) :35-40

[9] Synthetic phospho-oligosaccharide fragments of lipophosphoglycan as acceptors for Leishmania major alpha-D-mannosylphosphate transferase [J].

Brown, GM ;

Millar, AR ;

Masterson, C ;

Brimacombe, JS ;

Nikolaev, AV ;

Ferguson, MAJ .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1996, 242 (02) :410-416

[10]

CHAUDHURI G, 1988, MOL BIOCHEM PARASIT, V27, P181

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