Genetic variation in microRNA networks: the implications for cancer research

被引：1068

作者：

Ryan, Brid M. ^{[1
,2
]}

Robles, Ana I. ^{[1
]}

Harris, Curtis C. ^{[1
]}

机构：

[1] NCI, Human Carcinogenesis Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

[2] NCI, Canc Prevent Fellowship Program, Ctr Canc Training, NIH, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS CANCER | 2010年 / 10卷 / 06期

关键词：

SINGLE-NUCLEOTIDE POLYMORPHISMS; THYMIDYLATE-SYNTHASE GENE; BINDING-SITE POLYMORPHISM; BREAST-CANCER; MESSENGER-RNA; TARGET SITE; LUNG-CANCER; UNTRANSLATED REGION; INSERTION/DELETION POLYMORPHISM; POSTTRANSCRIPTIONAL REGULATION;

D O I：

10.1038/nrc2867

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Many studies have highlighted the role that microRNAs have in physiological processes and how their deregulation can lead to cancer. More recently, it has been proposed that the presence of single nucleotide polymorphisms in microRNA genes, their processing machinery and target binding sites affects cancer risk, treatment efficacy and patient prognosis. In reviewing this new field of cancer biology, we describe the methodological approaches of these studies and make recommendations for which strategies will be most informative in the future.

引用

页码：389 / 402

页数：14

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