Spontaneous resolution of chronic hepatitis C virus disease after withdrawal of immunosuppression

被引：39

作者：

Somsouk, MA

Lauer, GM

Casson, D

Terella, A

Day, CL

Walker, BD

Chung, RT

机构：

[1] Massachusetts Gen Hosp, Gastrointestinal Unit, Dept Med, Boston, MA 02114 USA

[2] Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02114 USA

[3] Harvard Univ, Sch Med, Boston, MA 02115 USA

来源：

GASTROENTEROLOGY | 2003年 / 124卷 / 07期

关键词：

D O I：

10.1016/S0016-5085(03)00391-3

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Approximately 85% of acute cases of hepatitis C infection result in chronic hepatitis. Spontaneous clearance of hepatitis C virus has been thought to occur exclusively after acute infection and is associated with a robust cellular immune response. We describe here a case of a renal transplant recipient who acquired posttransplant hepatitis C virus infection with rapid histological, progression but who subsequently experienced spontaneous viral clearance along with histological remission after removal of immunosuppression. Immunologic studies showed persistently strong cellular immune responses. This case underscores the importance of restoration of the immune system in the control of hepatitis C virus viremia and disease progression and the need to minimize or obviate immunosuppression in organ transplant recipients.

引用

页码：1946 / 1949

页数：4

共 12 条

[11] Human immunodeficiency virus infection modifies the natural history of chronic parenterally-acquired hepatitis C with an unusually rapid progression to cirrhosis [J].

Soto, B ;

SanchezQuijano, A ;

Rodrigo, L ;

delOlmo, JA ;

GarciaBengoechea, M ;

HernandezQuero, J ;

Rey, C ;

Abad, MA ;

Rodriguez, M ;

Gilabert, MS ;

Gonzalez, F ;

Miron, P ;

Caruz, A ;

Relimpio, F ;

Torronteras, R ;

Leal, M ;

Lissen, E .

JOURNAL OF HEPATOLOGY, 1997, 26 (01) :1-5

[12] Time course of histological changes in patients with a sustained biochemical and virological response to interferon-alpha therapy for chronic hepatitis C virus infection [J].

Tsubota, A ;

Kumada, H ;

Chayama, K ;

Arase, Y ;

Saitoh, S ;

Koida, I ;

Suzuki, Y ;

Kobayashi, M ;

Murashima, N ;

Ikeda, K .

JOURNAL OF HEPATOLOGY, 1997, 27 (01) :49-55

← 1 2 →