The BCL-2 Family Reunion

被引：1290

作者：

Chipuk, Jerry E. ^{[1
]}

Moldoveanu, Tudor ^{[1
]}

Llambi, Fabien ^{[1
]}

Parsons, Melissa J. ^{[1
]}

Green, Douglas R. ^{[1
]}

机构：

[1] St Jude Childrens Hosp, Dept Immunol, Memphis, TN 38105 USA

来源：

MOLECULAR CELL | 2010年 / 37卷 / 03期

关键词：

MITOCHONDRIAL-MEMBRANE PERMEABILIZATION; CYTOCHROME-C RELEASE; ENDOPLASMIC-RETICULUM; CELL SURVIVAL; DEPENDENT APOPTOSIS; FISSION MACHINERY; BH3-ONLY PROTEINS; INDUCED AUTOPHAGY; PROAPOPTOTIC BAX; TRANSGENIC MICE;

D O I：

10.1016/j.molcel.2010.01.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

B cell CLL/lymphoma-2 (BCL-2) and its relatives comprise the BCL-2 family of proteins, which were originally characterized with respect to their roles in controlling outer mitochondrial membrane integrity and apoptosis. Current observations expand BCL-2 family function to include numerous cellular pathways. Here we will discuss the mechanisms and functions of the BCL-2 family in the context of these pathways, highlighting the complex integration and regulation of the BCL-2 family in cell fate decisions.

引用

页码：299 / 310

页数：12

共 89 条

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