Complete nucleotide sequence of human NRAMP2 cDNA

被引：42

作者：

Kishi, F ^{[1
]}

Tabuchi, M ^{[1
]}

机构：

[1] Yamaguchi Univ, Ctr Gene Res, Yamaguchi 755, Japan

来源：

MOLECULAR IMMUNOLOGY | 1997年 / 34卷 / 12-13期

关键词：

natural resistance; NRAMP2; cDNA; gene family;

D O I：

10.1016/S0161-5890(97)00110-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mouse Lsh/Ity/Bcg locus regulates macrophage activation for antimicrobial activity against intracellular pathogens, and the Nramp1 gene was isolated as its candidate. In the present study, a full length cDNA for human NRAMP2 has been isolated and characterized. Nucleotide sequence analysis reveals that the cDNA, 4142 bp in length, coded for a protein of 561 amino acid residues with a molecular weight mass of 61456. Predicted amino acid sequence analysis of the NRAMP2 molecule indicates that NRAMP1 and NRAMP2 sequences share 64% identical residues overall, whereas only 21% at the NH2-terminal cytoplasmic domain, where the NRAMP1 molecule was associated with microtubules, was found to be identical. This suggests that the NH2-terminal region of the NRAMP2 molecule may have a particular function, different from that of the NRAMP 1 molecule. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：839 / 842

页数：4

共 19 条

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