Exotic emerging viral diseases: progress and challenges

被引:351
作者
Geisbert, TW [1 ]
Jahrling, PB [1 ]
机构
[1] USA, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA
关键词
D O I
10.1038/nm1142
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The agents causing viral hemorrhagic fever (VHF) are a taxonomically diverse group of viruses that may share commonalities in the process whereby they produce systemic and frequently fatal disease. Significant progress has been made in understanding the biology of the Ebola virus, one of the best known examples. This knowledge has guided our thinking about other VHF agents, including Marburg, Lassa, the South American arenaviruses, yellow fever, Crimean-Congo and Rift Valley fever viruses. Comparisons among VHFs show that a common pathogenic feature is their ability to disable the host immune response by attacking and manipulating the cells that initiate the antiviral response. Of equal importance, these comparisons highlight critical gaps in our knowledge of these pathogens.
引用
收藏
页码:S110 / S121
页数:12
相关论文
共 177 条
  • [1] Alibek K., 1999, Biohazard : the Chilling True Story of the Largest Covert Biological Weapons Program in the World, Told from the inside by the Man Who Ran It. New York: Random House
  • [2] C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans
    Alvarez, CP
    Lasala, F
    Carrillo, J
    Muñiz, O
    Corbí, AL
    Delgado, R
    [J]. JOURNAL OF VIROLOGY, 2002, 76 (13) : 6841 - 6844
  • [3] Inhibition of different lassa virus strains by alpha and gamma interferons and comparison with a less pathogenic arenavirus
    Asper, M
    Sternsdorf, T
    Hass, M
    Drosten, C
    Rhode, A
    Schmitz, H
    Günther, S
    [J]. JOURNAL OF VIROLOGY, 2004, 78 (06) : 3162 - 3169
  • [4] Lassa virus infection of human dendritic cells and macrophages is productive but fails to activate cells
    Baize, S
    Kaplon, J
    Faure, C
    Pannetier, D
    Georges-Courbot, MC
    Deubel, V
    [J]. JOURNAL OF IMMUNOLOGY, 2004, 172 (05) : 2861 - 2869
  • [5] Defective humoral responses and extensive intravascular apoptosis are associated with fatal outcome in Ebola virus-infected patients
    Baize, S
    Leroy, EM
    Georges-Courbot, MC
    Capron, M
    Lansoud-Soukate, J
    Debré, P
    Fisher-Hoch, SP
    McCormick, JB
    McCormick, JB
    Georges, AJ
    [J]. NATURE MEDICINE, 1999, 5 (04) : 423 - 426
  • [6] CONGO-CRIMEAN HEMORRHAGIC-FEVER IN DUBAI - HISTOPATHOLOGICAL STUDIES
    BASKERVILLE, A
    SATTI, AGO
    MURPHY, FA
    SIMPSON, DIH
    [J]. JOURNAL OF CLINICAL PATHOLOGY, 1981, 34 (08) : 871 - 874
  • [7] The Ebola virus VP35 protein functions as a type IIFN antagonist
    Basler, CF
    Wang, XY
    Mühlberger, E
    Volchkov, V
    Paragas, J
    Klenk, HD
    Garcia-Sastre, A
    Palese, P
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (22) : 12289 - 12294
  • [8] Basler CF, 2004, EBOLA AND MARBURG VIRUSES: MOLECULAR AND CELLULAR BIOLOGY, P305
  • [9] The Ebola virus VP35 protein inhibits activation of interferon regulatory factor 3
    Basler, CF
    Mikulasova, A
    Martinez-Sobrido, L
    Paragas, J
    Mühlberger, E
    Bray, M
    Klenk, HD
    Palese, P
    García-Sastre, A
    [J]. JOURNAL OF VIROLOGY, 2003, 77 (14) : 7945 - 7956
  • [10] THE ASIALOGLYCOPROTEIN RECEPTOR IS A POTENTIAL LIVER-SPECIFIC RECEPTOR FOR MARBURG VIRUS
    BECKER, S
    SPIESS, M
    KLENK, HD
    [J]. JOURNAL OF GENERAL VIROLOGY, 1995, 76 : 393 - 399