Resveratrol protects against experimental stroke: Putative neuroprotective role of heme oxygenase 1

被引：128

作者：

Sakata, Yoshihito ^{[1
]}

Zhuang, Hean ^{[1
]}

Kwansa, Herman ^{[1
]}

Koehler, Raymond C. ^{[1
]}

Dore, Sylvain ^{[1
]}

机构：

[1] Johns Hopkins Univ, Baltimore, MD 21205 USA

来源：

EXPERIMENTAL NEUROLOGY | 2010年 / 224卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Cerebral ischemia; Neuroprotection; Polyphenol; Red wine; Stilbene; CORONARY-HEART-DISEASE; CEREBRAL-ISCHEMIA; WINE; PREVENTION; QUERCETIN; ALCOHOL; NEURONS; HEALTH; MICE;

D O I：

10.1016/j.expneurol.2010.03.032

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Epidemiological and experimental reports have linked mild-to-moderate wine and/or grape consumption to a lowered incidence of cardiovascular, cerebrovascular, and peripheral vascular risk. This study revealed that resveratrol, an enriched bioactive polyphenol in red wine, selectively induces heme oxygenase 1 (HO1) in a dose- and time-dependent manner in cultured mouse cortical neuronal cells and provides neuroprotection from free-radical or excitotoxicity damage. This protection was lost when cells were treated with a protein synthesis or heme oxygenase inhibitor, suggesting that HO1 induction is at least partially required for resveratrol's prophylactic properties. Furthermore, resveratrol pretreatment dose-dependently protected mice subjected to an optimized ischemic-reperfusion stroke model. Mice in which HO1 was selectively deleted lost most, if not all, of the beneficial effects. Together, the data suggest a potential intracellular pathway by which resveratrol can provide cell/organ resistance against neuropathological conditions. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：325 / 329

页数：5

共 19 条

[1] Oxyresveratrol (trans-2,3′,4,5′-tetrahydroxystilbene) is neuroprotective and inhibits the apoptotic cell death in transient cerebral ischemia [J].