MicroRNA Gene Regulatory Pathways in the Establishment and Maintenance of ESC Identity

被引：113

作者：

Martinez, Natalia J. ^{[1
]}

Gregory, Richard I. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol,Stem Cell Program, Harvard Stem Cell Inst,Childrens Hosp Boston, Boston, MA 02115 USA

来源：

CELL STEM CELL | 2010年 / 7卷 / 01期

关键词：

STEM; BIOGENESIS; OCT4; SOX2;

D O I：

10.1016/j.stem.2010.06.011

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Understanding the molecular foundations of embryonic stem cell (ESC) self-renewal and pluripotency will facilitate therapeutic exploitation of these remarkable cells. Here we discuss the emerging roles of microRNAs in the establishment and maintenance of ESC identity and summarize our current understanding of the mechanisms controlling microRNA expression and function in ESCs.

引用

页码：31 / 35

页数：5