Regulation of competence for genetic transformation in Streptococcus pneumoniae:: a link between quorum sensing and DNA processing genes

被引：50

作者：

Morrison, DA ^{[1
]}

Lee, MS ^{[1
]}

机构：

[1] Univ Illinois, Dept Biol Sci, Mol Biol Lab, Chicago, IL 60680 USA

来源：

RESEARCH IN MICROBIOLOGY | 2000年 / 151卷 / 06期

关键词：

Streptococcus pneumoniae; quorum sensing; regulon; genetic transformation; peptide pheromone;

D O I：

10.1016/S0923-2508(00)00171-6

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Competence for genetic transformation in pneumococcus depends on the coordinated functioning of a dispersed regulon responsible for production of proteins active in DNA binding, uptake, and recombination. This regulon is characterized by a shared noncanonical promoter consensus, TACGAATA, and is capable of 100-fold expression modulations. This review discusses recent evidence that its regulation depends on a novel sigma factor, itself controlled by an autostimulatory quorum sensing system that acts through an extracellular peptide signal. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

引用

页码：445 / 451

页数：7

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