Regulation of cell death: The calcium-apoptosis link

被引：2441

作者：

Orrenius, S

Zhivotovsky, B

Nicotera, P

机构：

[1] Karolinska Inst, Div Toxicol, Inst Environm Med, SE-17177 Stockholm, Sweden

[2] Univ Leicester, MRC, Toxicol Unit, Leicester LE1 9HN, Leics, England

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2003年 / 4卷 / 07期

关键词：

D O I：

10.1038/nrm1150

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

To live or to die? This crucial question eloquently reflects the dual role of Ca2+ in living organisms - survival factor or ruthless killer. It has long been known that Ca2+ signals govern a host of vital cell functions and so are necessary for cell survival. However, more recently it has become clear that cellular Ca2+ overload, or perturbation of intracellular Ca2+ compartmentalization, can cause cytotoxicity and trigger either apoptotic or necrotic cell death.

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页码：552 / 565

页数：14

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