Role of histone modification in chromatin dynamics

被引：86

作者：

Ito, Takashi ^{[1
]}

机构：

[1] Nagasaki Univ, Sch Med, Dept Biochem, Nagasaki 8528523, Japan

来源：

JOURNAL OF BIOCHEMISTRY | 2007年 / 141卷 / 05期

关键词：

chromatin; histone code; NHK-1; nucleosome; modification; transcription;

D O I：

10.1093/jb/mvm091

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The covalent modification of histone tails has emerged as a crucial step in controlling the eucaryotic genomes. Eucaryotic cells must possess mechanisms for condensing and decondensing chromatin. Moreover, chromatin condensation is particularly evident during mitosis and apoptotic cell death, whereas chromatin relaxation is necessary for replication, repair, recombination and transcription. The post-translational modifications of histone tails such as reversible acetylation, phosphorylation and methylation play a critical role in dynamic condensation/relaxation that occurs during the cell cycle. Histone phosphorylation is believed to play a direct role in mitosis, cell death, repair, replication and recombination. In this review, we discuss recent progress in studies of histone phosphorylation.

引用

页码：609 / 614

页数：6

共 61 条

[21] Regulation of HP1-chromatin binding by histone H3 methylation and phosphorylation [J].

Fischle, W ;

Tseng, BS ;

Dormann, HL ;

Ueberheide, BM ;

Garcia, BA ;

Shabanowitz, J ;

Hunt, DF ;

Funabiki, H ;

Allis, CD .

NATURE, 2005, 438 (7071) :1116-1122

[22] Mitogen-activated protein kinase cascade-mediated histone H3 phosphorylation is critical for telornerase reverse transcriptase expression/telomerase activation induced by proliferation [J].

Ge, Z ;

Liu, C ;

Björkholm, M ;

Gruber, A ;

Xu, DW .

MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (01) :230-237

[23] Identification of a novel phosphorylation site on histone H3 coupled with mitotic chromosome condensation [J].

Goto, H ;

Tomono, Y ;

Ajiro, K ;

Kosako, H ;

Fujita, M ;

Sakurai, M ;

Okawa, K ;

Iwamatsu, A ;

Okigaki, T ;

Takahashi, T ;

Inagaki, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (36) :25543-25549

[24] Aurora-B phosphorylates histone H3 at serine28 with regard to the mitotic chromosome condensation [J].

Goto, H ;

Yasui, Y ;

Nigg, EA ;

Inagaki, M .

GENES TO CELLS, 2002, 7 (01) :11-17

[25] Serine 31 phosphorylation of histone variant H3.3 is specific to regions bordering centromeres in metaphase chromosomes [J].

Hake, SB ;

Garcia, BA ;

Kauer, M ;

Baker, SP ;

Shabanowitz, J ;

Hunt, DF ;

Allis, CD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (18) :6344-6349

[26] Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation [J].

Hendzel, MJ ;

Wei, Y ;

Mancini, MA ;

VanHooser, A ;

Ranalli, T ;

Brinkley, BR ;

BazettJones, DP ;

Allis, CD .

CHROMOSOMA, 1997, 106 (06) :348-360

[27] Histone H3 serine 10 phosphorylation by Aurora B causes HP1 dissociation from heterochromatin [J].

Hirota, T ;

Lipp, JJ ;

Toh, BH ;

Peters, JM .

NATURE, 2005, 438 (7071) :1176-1180

[28] Mitotic phosphorylation of histone H3 is governed by IpI1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes [J].

Hsu, JY ;

Sun, ZW ;

Li, XM ;

Reuben, M ;

Tatchell, K ;

Bishop, DK ;

Grushcow, JM ;

Brame, CJ ;

Caldwell, JA ;

Hunt, DF ;

Lin, RL ;

Smith, MM ;

Allis, CD .

CELL, 2000, 102 (03) :279-291

[29] Cytometric assessment of DNA damage in relation to cell cycle phase and apoptosis [J].

Huang, X ;

Halicka, HD ;

Traganos, F ;

Tanaka, T ;

Kurose, A ;

Darzynkiewicz, Z .

CELL PROLIFERATION, 2005, 38 (04) :223-243

[30] Chromatin assembly factors: a dual function in nucleosome formation and mobilization? [J].

Ito, T ;

Tyler, JK ;

Kadonaga, LT .

GENES TO CELLS, 1997, 2 (10) :593-600

← 1 2 3 4 5 6 7 →