How did alternative splicing evolve?

被引：435

作者：

Ast, G ^{[1
]}

机构：

[1] Tel Aviv Univ, Dept Human Genet & Mol Med, Sackler Fac Med, IL-69978 Tel Aviv, Israel

来源：

NATURE REVIEWS GENETICS | 2004年 / 5卷 / 10期

关键词：

D O I：

10.1038/nrg1451

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Alternative splicing creates transcriptome diversification, possibly leading to speciation. A large fraction of the protein-coding genes of multicellular organisms are alternatively spliced, although no regulated splicing has been detected in unicellular eukaryotes such as yeasts. A comparative analysis of unicellular and multicellular eukaryotic 5' splice sites has revealed important differences-the plasticity of the 5' splice sites of multicellular eukaryotes means that these sites can be used in both constitutive and alternative splicing, and for the regulation of the inclusion/skipping ratio in alternative splicing. So, alternative splicing might have originated as a result of relaxation of the 5' splice site recognition in organisms that originally could support only constitutive splicing.

引用

页码：773 / 782

页数：10

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