How did alternative splicing evolve?

被引：435

作者：

Ast, G ^{[1
]}

机构：

[1] Tel Aviv Univ, Dept Human Genet & Mol Med, Sackler Fac Med, IL-69978 Tel Aviv, Israel

来源：

NATURE REVIEWS GENETICS | 2004年 / 5卷 / 10期

关键词：

D O I：

10.1038/nrg1451

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Alternative splicing creates transcriptome diversification, possibly leading to speciation. A large fraction of the protein-coding genes of multicellular organisms are alternatively spliced, although no regulated splicing has been detected in unicellular eukaryotes such as yeasts. A comparative analysis of unicellular and multicellular eukaryotic 5' splice sites has revealed important differences-the plasticity of the 5' splice sites of multicellular eukaryotes means that these sites can be used in both constitutive and alternative splicing, and for the regulation of the inclusion/skipping ratio in alternative splicing. So, alternative splicing might have originated as a result of relaxation of the 5' splice site recognition in organisms that originally could support only constitutive splicing.

引用

页码：773 / 782

页数：10

共 80 条

[41] Frequent alternative splicing of human genes [J].

Mironov, AA ;

Fickett, JW ;

Gelfand, MS .

GENOME RESEARCH, 1999, 9 (12) :1288-1293

[42] Alternative splicing in the human, mouse and rat genomes is associated with an increased frequency of exon creation and/or loss [J].

Modrek, B ;

Lee, CJ .

NATURE GENETICS, 2003, 34 (02) :177-180

[43] A genomic view of alternative splicing [J].

Modrek, B ;

Lee, C .

NATURE GENETICS, 2002, 30 (01) :13-19

[44]

Moss L., 2003, WHAT GENES CANT DO

[45] Multiple splice variants encode a novel adenylyl cyclase of possible plastid origin expressed in the sexual stage of the malaria parasite Plasmodium falciparum [J].

Muhia, DK ;

Swales, CA ;

Eckstein-Ludwig, U ;

Saran, S ;

Polley, SD ;

Kelly, JM ;

Schaap, P ;

Krishna, S ;

Baker, DA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (24) :22014-22022

[46] MUTATIONS IN U1 SNRNA BYPASS THE REQUIREMENT FOR A CELL TYPE-SPECIFIC RNA SPLICING FACTOR [J].

NANDABALAN, K ;

PRICE, L ;

ROEDER, GS .

CELL, 1993, 73 (02) :407-415

[47] Splicing regulation as a potential genetic modifier [J].

Nissim-Rafinia, M ;

Kerem, B .

TRENDS IN GENETICS, 2002, 18 (03) :123-127

[48] Low conservation of alternative splicing patterns in the human and mouse genomes [J].

Nurtdinov, RN ;

Artamonova, II ;

Mironov, AA ;

Gelfand, MS .

HUMAN MOLECULAR GENETICS, 2003, 12 (11) :1313-1320

[49] Mutations in U5 snRNA loop 1 influence the splicing of different genes in vivo [J].

O'Keefe, RT .

NUCLEIC ACIDS RESEARCH, 2002, 30 (24) :5476-5484

[50] MRNAs encoding zinc finger protein isoforms are expressed by alternative splicing of an in-frame intron in fission yeast [J].

Okazaki, K ;

Niwa, O .

DNA RESEARCH, 2000, 7 (01) :27-30

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