Detection of explosives by olfactory sensory neurons

被引：28

作者：

Corcelli, Angela ^{[1
]}

Lobasso, Simona ^{[1
]}

Lopalco, Patrizia ^{[1
]}

Dibattista, Michele ^{[2
]}

Araneda, Ricardo ^{[3
]}

Peterlin, Zita ^{[4
]}

Firestein, Stuart ^{[4
]}

机构：

[1] Univ Bari, Dept Med Biochem Med Biol & Med Phys, Bari, Italy

[2] SISSA, Neurobiol Sector, I-34014 Trieste, Italy

[3] Univ Maryland, Dept Biol, College Pk, MD 20742 USA

[4] Columbia Univ, Dept Biol Sci, New York, NY 10027 USA

来源：

JOURNAL OF HAZARDOUS MATERIALS | 2010年 / 175卷 / 1-3期

关键词：

TNT; RDX; Olfactory sensory neuron; Isolated cilia; Calcium imaging; CILIA; RECEPTORS; ODORANTS; YEAST;

D O I：

10.1016/j.jhazmat.2009.10.054

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The response of olfactory sensory neurons to TNT and RDX as well as to some volatile organic compounds present in the vapors of antipersonnel landmines has been studied both in the pig and in the rat. GC/MS analyses of different plastic components of six different kinds of landmines were performed in order to identify the components of the "perfume" of mines. Studies on rat olfactory mucosa were carried out with electro-olfactogram and calcium imaging techniques, while changes in the cyclic adenosine monophosphate (cAMP) levels following exposure to odorants and explosives were used as a criterion to evaluate the interaction of TNT and RDX with olfactory receptors in a preparation of isolated pig olfactory cilia. These studies indicate that chemical compounds associated with explosives and explosive devices can activate mammalian olfactory receptors. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：1096 / 1100

页数：5

共 13 条

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