Analysis of heterocyclic aromatic amines in wine by high-performance liquid chromatography electrospray tandem mass spectrometry

被引：55

作者：

Richling, E ^{[1
]}

Decker, C ^{[1
]}

Häring, D ^{[1
]}

Herderich, M ^{[1
]}

Schreier, P ^{[1
]}

机构：

[1] Univ Wurzburg, Lehrstuhl Lebensmittelchem, D-97074 Wurzburg, Germany

来源：

JOURNAL OF CHROMATOGRAPHY A | 1997年 / 791卷 / 1-2期

关键词：

wine; amines; heterocyclic aromatic;

D O I：

10.1016/S0021-9673(97)00842-X

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

High-performance liquid chromatography-electrospray tandem mass spectrometry (HPLC-ESI-MS-MS) was used for the analysis of heterocyclic aromatic amines (HAAs) in 25 wines from various regions. In 24 wines under study HAAs were detected in the low ng/l range. 2-Amino-3,4-dimethyl-3H-imidazo[4,5-f]quinoxaline (MeIQx) and 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeA alpha C) were found to be the most widely distributed HAAs in the wines under study. There was a difference in the presence of HAAs in white and red wines. In the latter, higher concentrations were found, with MeA alpha C in amounts ranging from <7.5 to 107 ng/l. Compared to the quantities of HAAs evaluated in meat and meat products, the amounts found in wines are 100-1000-fold lower. (C) 1997 Elsevier Science B.V.

引用

页码：71 / 77

页数：7

共 23 条

[1] DETERMINATION OF BETA-CARBOLINES IN FOODSTUFFS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY AND HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY MASS-SPECTROMETRY [J].

ADACHI, J ;

MIZOI, Y ;

NAITO, T ;

YAMAMOTO, K ;

FUJIWARA, S ;

NINOMIYA, I .

JOURNAL OF CHROMATOGRAPHY, 1991, 538 (02) :331-339

[2]

EADES DM, 1995, P 43 ASMS C ATL GA, P500

[3] FOOD-BORNE HETEROCYCLIC AMINES - CHEMISTRY, FORMATION, OCCURRENCE AND BIOLOGICAL-ACTIVITIES - A LITERATURE-REVIEW [J].

EISENBRAND, G ;

TANG, W .

TOXICOLOGY, 1993, 84 (1-3) :1-82

[4] OPTIMIZATION OF THE SENSITIVITY OF HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY IN THE DETECTION OF HETEROCYCLIC AROMATIC AMINE MUTAGENS [J].

GROSS, GA ;

GRUTER, A ;

HEYLAND, S .

FOOD AND CHEMICAL TOXICOLOGY, 1992, 30 (06) :491-498

[5] HETEROCYCLIC AROMATIC AMINE FORMATION IN GRILLED BACON, BEEF AND FISH AND IN GRILL SCRAPINGS [J].

GROSS, GA ;

TURESKY, RJ ;

FAY, LB ;

STILLWELL, WG ;

SKIPPER, PL ;

TANNENBAUM, SR .

CARCINOGENESIS, 1993, 14 (11) :2313-2318

[6]

HARVEY DG, 1992, J CHEM SOC, V153, P153

[7]

Jacobs WA, 1936, J BIOL CHEM, V113, P759

[8] FORMATION OF HETEROCYCLIC AMINES USING MODEL SYSTEMS [J].

JAGERSTAD, M ;

SKOG, K ;

GRIVAS, S ;

OLSSON, K .

MUTATION RESEARCH, 1991, 259 (3-4) :219-233

[9] CHARACTERIZATION OF MUTAGENIC ACTIVITY IN INSTANT HOT BEVERAGE POWDERS [J].

JOHANSSON, MAE ;

KNIZE, MG ;

JAGERSTAD, M ;

FELTON, JS .

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 1995, 25 (02) :154-161

[10] EUDISTOMINS FROM THE NEW-ZEALAND ASCIDIAN RITTERELLA-SIGILLINOIDES [J].

LAKE, RJ ;

BLUNT, JW ;

MUNRO, MHG .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1989, 42 (07) :1201-1206

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