Circulating 25-Hydroxyvitamin D and Risk of Non-Hodgkin Lymphoma

被引：56

作者：

Purdue, Mark P. ^{[1
]}

Freedman, D. Michal ^{[1
]}

Gapstur, Susan M. ^{[2
]}

Helzlsouer, Kathy J. ^{[3
,4
]}

Laden, Francine ^{[5
,6
,7
]}

Lim, Unhee ^{[9
]}

Maskarinec, Gertraud ^{[9
]}

Rothman, Nathaniel ^{[1
]}

Shu, Xiao-Ou ^{[10
]}

Stevens, Victoria L. ^{[2
]}

Zeleniuch-Jacquotte, Anne ^{[11
]}

Albanes, Demetrius ^{[1
]}

Bertrand, Kimberly ^{[7
]}

Weinstein, Stephanie J. ^{[1
]}

Yu, Kai ^{[1
]}

Irish, Lonn ^{[12
]}

Horst, Ronald L. ^{[13
]}

Hoffman-Bolton, Judith ^{[3
]}

Giovannucci, Edward L. ^{[7
,8
]}

Kolonel, Laurence N. ^{[9
]}

Snyder, Kirk ^{[12
]}

Willett, Walter ^{[5
,7
,8
]}

Arslan, Alan A. ^{[11
]}

Hayes, Richard B. ^{[11
]}

Zheng, Wei ^{[10
]}

Xiang, Yong-Bing ^{[14
]}

Hartge, Patricia ^{[1
]}

机构：

[1] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

[2] Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA

[3] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[4] Mercy Med Ctr, Weinberg Ctr Womens Hlth & Med, Prevent & Res Ctr, Baltimore, MD USA

[5] Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA

[6] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA

[7] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[8] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

[9] Univ Hawaii, Canc Res Ctr, Honolulu, HI 96813 USA

[10] Vanderbilt Univ, Sch Med, Vanderbilt Epidemiol Ctr, Vanderbilt Ingram Canc Ctr,Div Epidemiol,Dept Med, Nashville, TN 37212 USA

[11] NYU, Inst Canc, Sch Med, New York, NY USA

[12] Informat Management Serv Inc, Silver Spring, MD USA

[13] Heartland Assays Inc, Ames, IA USA

[14] Shanghai Canc Inst, Shanghai, Peoples R China

来源：

AMERICAN JOURNAL OF EPIDEMIOLOGY | 2010年 / 172卷 / 01期

基金：

美国国家卫生研究院;

关键词：

calcifediol; calcitrol; case-control studies; cohort studies; 25-hydroxyvitamin D 2; lymphoma; non-Hodgkin; prospective studies; vitamin D; ULTRAVIOLET-RADIATION EXPOSURE; VITAMIN-D-RECEPTOR; SUN EXPOSURE; UNITED-STATES; SUNLIGHT; MORTALITY; CANCERS;

D O I：

10.1093/aje/kwq117

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Case-control studies generally suggesting an inverse association between sun exposure and non-Hodgkin lymphoma (NHL) have led to speculation that vitamin D may protect against lymphomagenesis. To examine this hypothesis, the authors conducted a pooled investigation of circulating 25-hydroxyvitamin D (25(OH)D) and subsequent NHL risk within 10 cohorts participating in the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. The authors analyzed measurements from 1,353 cases and 1,778 controls using conditional logistic regression and other methods to estimate the association of 25(OH)D with NHL. No clear evidence of association between categories of 25(OH)D concentration and NHL was observed overall (P(trend) = 0.68) or by sex (men, P(trend) = 0.50; women, P(trend) = 0.16). Findings for other measures (continuous log(25(OH)D), categories of 25(OH)D using sex-/cohort-/season-specific quartiles as cutpoints, categories of season-adjusted residuals of predicted 25(OH)D using quartiles as cutpoints) were generally null, although some measures of increasing 25(OH)D were suggestive of an increased risk for women. Results from stratified analyses and investigations of histologic subtypes of NHL were also null. These findings do not support the hypothesis that elevated circulating 25(OH)D concentration is associated with a reduced risk of NHL. Future research investigating the biologic basis for the sunlight-NHL association should consider alternative mechanisms, such as immunologic effects.

引用

页码：58 / 69

页数：12

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