Ribonuclease inhibits Kaposi's sarcoma

被引：30

作者：

Griffiths, SJ ^{[1
]}

Adams, DJ ^{[1
]}

Talbot, SJ ^{[1
]}

机构：

[1] INST CANC RES,LONDON SW3 6JB,ENGLAND

来源：

NATURE | 1997年 / 390卷 / 6660期

关键词：

D O I：

10.1038/37510

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Kaposi's sarcoma (KS) is a cancer closely associated with AIDS. Crude, commercial human urinary chorionic gonadotrophin (hCG) preparations have previously been found to inhibit the growth of KS cell lines in vitroand in immunodeficient mice1,2, and to induce tumour regression of KS lesions in AIDS patients3,4. Here we report the purification of a ribonuclease (RNase) from a commercial hCG preparation. The pure enzyme killed KS cells in vitro,apparently by apoptosis, suggesting that effects of commercial hCG preparations on KS cells and tumours are due, at least in part, to RNase present as a contaminant in these preparations.

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页码：568 / 568

页数：1

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