TUMORIGENESIS AND METASTASIS OF NEOPLASTIC KAPOSIS-SARCOMA CELL-LINE IN IMMUNODEFICIENT MICE BLOCKED BY A HUMAN-PREGNANCY HORMONE

被引:204
作者
LUNARDIISKANDAR, Y
BRYANT, JL
ZEMAN, RA
LAM, VH
SAMANIEGO, F
BESNIER, JM
HERMANS, P
THIERRY, AR
GILL, P
GALLO, RC
机构
[1] NCI, TUMOR CELL BIOL LAB, BETHESDA, MD 20892 USA
[2] NIDR, ANIM CARE UNIT, BETHESDA, MD 20892 USA
[3] GYNECOL & OBSTET MED CTR, F-75017 PARIS, FRANCE
[4] FREE UNIV BRUSSELS, HOP ST PIERRE, DEPT MALAD INFECT, B-1000 BRUSSELS, BELGIUM
[5] UNIV SO CALIF, SCH MED, LOS ANGELES, CA 90033 USA
关键词
D O I
10.1038/375064a0
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
KAPOSI's sarcoma (KS) occurs more often in men than in women and HIV-1-associated KS has a high occurrence in homosexual men (over 30%). Most cultures of KS tumours yield cells with properties of hyperplastic (not malignant) endothelial cells under the control of several cytokines(1-7). The role of HIV-1 may be in promoting high levels of some cytokines and providing stimulation to angiogenesis by the HIV-1 Tat protein(8), which synergizes with basic fibroblast growth factor in promoting these effects(9), Here,ve describe an immortalized AIDS-KS cell line (KS Y-1) and show that these cells produce malignant metastatic tumours in nude mice and are killed in vitro and in vivo (apparently by apoptosis) by a pregnancy hormone, the beta-chain of human chorionic gonadotropin. Similarly, chorionic gonadotropin kills KS SLK, cells from another neoplastic cell line (established from a non-HIV-associated KS)(10), as well as the hyperplastic KS cells from clinical specimens grown in short-term culture, but does not kill normal endothelial cells, These results provide evidence that KS can evolve into a malignancy and have implications for the hormonal treatment of this tumour.
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页码:64 / 68
页数:5
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