Examination of the expanding pathways for the regulation of p21 expression and activity

被引：371

作者：

Jung, Yong-Sam ^{[1
]}

Qian, Yingjuan ^{[1
]}

Chen, Xinbin ^{[1
]}

机构：

[1] Univ Calif Davis, Ctr Comparat Oncol, Davis, CA 95616 USA

来源：

CELLULAR SIGNALLING | 2010年 / 22卷 / 07期

关键词：

p53; p21(Waf1/Cip1/Sdi); MicroRNA; RNA-binding proteins; mRNA stability; Transcription; RNA-BINDING PROTEIN; NUCLEOTIDE EXCISION-REPAIR; CYCLIN-DEPENDENT KINASES; CELL NUCLEAR ANTIGEN; CDK INHIBITOR P21; HISTONE DEACETYLASE INHIBITORS; P21(WAF1) MESSENGER-RNA; 3/P21; COMPLEX-FORMATION; PROLYL ISOMERASE PIN1; DNA-REPLICATION;

D O I：

10.1016/j.cellsig.2010.01.013

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

p21(Waf1/Cip1/Sdi1) was originally identified as an inhibitor of cyclin-dependent kinases, a mediator of p53 in growth suppression and a marker of cellular senescence. p21 is required for proper cell cycle progression and plays a role in cell death, DNA repair, senescence and aging, and induced pluripotent stem cell reprogramming. Although transcriptional regulation is considered to be the initial control point for p21 expression, there is growing evidence that post-transcriptional and post-translational regulations play a critical role in p21 expression and activity. This review will briefly discuss the activity of p21 and focus on current knowledge of the determinants that control p21 transcription, mRNA stability and translation, and protein stability and activity. Published by Elsevier Inc.

引用

页码：1003 / 1012

页数：10

共 221 条

[71] Suppression of induced pluripotent stem cell generation by the p53-p21 pathway [J].

Hong, Hyenjong ;

Takahashi, Kazutoshi ;

Ichisaka, Tomoko ;

Aoi, Takashi ;

Kanagawa, Osami ;

Nakagawa, Masato ;

Okita, Keisuke ;

Yamanaka, Shinya .

NATURE, 2009, 460 (7259) :1132-1135

[72] Competition of CUGBP1 and calreticulin for the regulation of p21 translation determines cell fate [J].

Iakova, P ;

Wang, GL ;

Timchenko, L ;

Michalak, M ;

Pereira-Smith, OM ;

Smith, JR ;

Timchenko, NA .

EMBO JOURNAL, 2004, 23 (02) :406-417

[73] MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression [J].

Ivanovska, Irena ;

Ball, Alexey S. ;

Diaz, Robert L. ;

Magnus, Jill F. ;

Kibukawa, Miho ;

Schelter, Janell M. ;

Kobayashi, Sumire V. ;

Lim, Lee ;

Burchard, Juja ;

Jackson, Aimee L. ;

Linsley, Peter S. ;

Cleary, Michele A. .

MOLECULAR AND CELLULAR BIOLOGY, 2008, 28 (07) :2167-2174

[74] Regulation of p21WAF1/CIP1 stability by WISp39, a Hsp90 binding TPR protein [J].

Jascur, T ;

Brickner, H ;

Salles-Passador, I ;

Barbier, V ;

El Khissiin, A ;

Smith, B ;

Fotedar, R ;

Fotedar, A .

MOLECULAR CELL, 2005, 17 (02) :237-249

[75] Induction of p21Waf1/Cip1 by TNFα requires NF-κB activity and antagonizes apoptosis in Ewing tumor cells [J].

Javelaud, D ;

Wietzerbin, J ;

Delattre, O ;

Besançon, F .

ONCOGENE, 2000, 19 (01) :61-68

[76] MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation [J].

Jin, YT ;

Lee, HJ ;

Zeng, SLX ;

Dai, MS ;

Lu, H .

EMBO JOURNAL, 2003, 22 (23) :6365-6377

[77] Proliferating cell nuclear antigen: more than a clamp for DNA polymerases [J].

Jonsson, ZO ;

Hubscher, U .

BIOESSAYS, 1997, 19 (11) :967-975

[78] p21waf1 mRNA contains a conserved element in its 3′-untranslated region that is bound by the Elav-like mRNA-stabilizing proteins [J].

Joseph, B ;

Orlian, M ;

Furneaux, H .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (32) :20511-20516

[79] AP4 encodes a c-MYC-inducible repressor of p21 [J].

Jung, Peter ;

Menssen, Antje ;

Mayr, Doris ;

Hermeking, Heiko .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (39) :15046-15051

[80]

KAO PN, 1994, J BIOL CHEM, V269, P20691

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