Effects of fluvoxamine on levels of dopamine, serotonin, and their metabolites in the hippocampus elicited by isolation housing and novelty stress in adult rats

被引：23

作者：

Miura, H ^{[1
]}

Qiao, H ^{[1
]}

Kitagami, T ^{[1
]}

Ohta, T ^{[1
]}

Ozaki, N ^{[1
]}

机构：

[1] Nagoya Univ, Sch Med, Dept Psychiat, Showa Ku, Nagoya, Aichi 4668550, Japan

来源：

INTERNATIONAL JOURNAL OF NEUROSCIENCE | 2005年 / 115卷 / 03期

关键词：

dopamine; fluvoxamine; hippocampus; isolation housing; novelty stress; serotonin;

D O I：

10.1080/00207450590520984

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The authors investigated the effects of fluvoxamine on neurochemical changes in the hippocampus elicited by isolation housing and novelty stress. Male F344 rats (11 w) were housed one per cage for four weeks. On each day of the last week (7 days) they were s.c. injected with fluvoxamine (20 mg/kg), and then subjected to novelty stress. Isolation housing significantly increased dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindoleacetic acid (5-HIAA) levels, whereas fluvoxamine significantly decreased them. Isolation housing significantly increased the DOPAC/DA ratio. Fluvoxamine significantly decreased the DA level, and partially restored the DOPAC and 5-HIAA levels increased by isolation housing.

引用

页码：367 / 378

页数：12

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